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Orthodenticle Homeobox 2 (OTX2) antibody

Details for Product No. ABIN650157
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Antigen
Synonyms CPHD6, MCOPS5, E130306E05Rik, id:ibd2915, zOtx2, zgc:136535, zotx-2, Xotx-2, Xotx2, otx-2, otx2
Reactivity
Human
(50), (19), (18), (15), (15), (15), (3), (3), (2), (1)
Host
Rabbit
(35), (16), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(42), (28), (25), (14), (10), (8), (7), (5), (1), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN650157
392.86 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity A synthetic peptide corresponding to residues in human OTX2 was used as an immunogen.
Alternative Name OTX2
Background Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1), more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).
Molecular Weight 32 kDA
Gene ID 5015
UniProt P32243
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000
Comment

Background: Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1), more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment OTX2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Vernay, Koch, Vaccarino et al.: "Otx2 regulates subtype specification and neurogenesis in the midbrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 19, pp. 4856-67, 2005 (PubMed).

Chatelain, Fossat, Brun et al.: "Molecular dissection reveals decreased activity and not dominant negative effect in human OTX2 mutants." in: Journal of molecular medicine (Berlin, Germany), Vol. 84, Issue 7, pp. 604-15, 2006 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Henderson, Williamson, Kennedy et al.: "A rare de novo nonsense mutation in OTX2 causes early onset retinal dystrophy and pituitary dysfunction." in: Molecular vision, Vol. 15, pp. 2442-7, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650157
392.86 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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