Actin Related Protein 2/3 Complex, Subunit 5, 16kDa (ARPC5) (N-Term) antibody

Details for Product No. ABIN650170
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Antigen
Synonyms APOBEC4, ARPC5, arc16, p16-arc, MGC86407, 5830443F10Rik, p16-Arc, ARC16, dJ127C7.3
Epitope
N-Term
(3), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(22), (17), (15), (12), (1)
Host
Rabbit
(19), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(14), (10), (6), (5), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN650170
450.00 $
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Immunogen A synthetic peptide corresponding to residues on the N-terminus of human p16-ARC was used as an immunogen.
Specificity A synthetic peptide corresponding to residues on the N-terminus of human p16-ARC was used as an immunogen.
Alternative Name p16-Arc
Background The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc (p complex) (1). These proteins localize in the cytoplasm of fibroblasts that lack lamellipodia, but are enriched in lamellipodia on stimulation with serum or platelet-derived growth factor. A dynamic role for this complex in the organization of the actin cytoskeleton has been suggested (2). p16-Arc has been found to be a globular alpha-helical subunit (3).
Synonyms: SRM, SPS1, SRML1, Spermidine synthase, Putrescine aminopropyltransferase
Molecular Weight 16 kDA
Gene ID 10092
UniProt O15511
Research Area Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:1000-10000
Comment

Background: The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc (p complex) (1). These proteins localize in the cytoplasm of fibroblasts that lack lamellipodia, but are enriched in lamellipodia on stimulation with serum or platelet-derived growth factor. A dynamic role for this complex in the organization of the actin cytoskeleton has been suggested (2). p16-Arc has been found to be a globular alpha-helical subunit (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment p16-Arc Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Welch, DePace, Verma et al.: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, 1997 (PubMed).

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