Mitogen-Activated Protein Kinase 14 (MAPK14) antibody

Antigen: Mitogen-Activated Protein Kinase 14 (MAPK14)

Synonyms: RK, p38, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA, Hog, CRK1, CSBP, Exip, Csbp1, Csbp2, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, MGC105413, p38b, zp38b, MAPK14, MGC142910, 186F5S, BG:DS00797.3, D-p38, D-p38b, Dm p38b, Dp38, ESTS:186F5S, Mpk34C, anon-sts23, p38 MAPK, p38 beta, p38B, p38beta, DmelCG7393, CG7393

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Certificates: ISO 9001:2008

Catalog no.: ABIN650180

Additional Information

Alternative name: p38 MAPK

Gene ID: 1432

UniProt: Q16539

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human p38 MAP kinase was used as immunogen. Predicted to react with CSBP1 splice form based on sequence homology.

Description: Other names: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, Mitogen-activated protein kinase 14, MAX-interacting protein 2,MAP kinase MXI2,SAPK2A

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near the C-terminus of human p38 MAP kinase was used as immunogen. Predicted to react with CSBP1 splice form based on sequence homology.

Molecular Weight: 42 kDA

Comments:

Background: p38 MAP kinase is a mitogen-activated protein kinase that functions in various intracellular signaling cascades controlling cellular stress responses. p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-3). MKK3 and SEK activate p38 MAP kinase by phosphorylation at adjacent threonine and tyrosine residues, Thr180 and Tyr182 (3,4). Activated p38 MAP kinase phosphorylates numerous downstream targets, including transcription factor ATF-2 (4).

Synonyms: RK, p38, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA, Hog, CRK1, CSBP, Exip, Csbp1, Csbp2, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, MGC105413, p38b, zp38b, MAPK14, MGC142910, 186F5S, BG:DS00797.3, D-p38, D-p38b, Dm p38b, Dp38, ESTS:186F5S, Mpk34C, anon-sts23, p38 MAPK, p38 beta, p38B, p38beta, DmelCG7393, CG7393

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: p38 MAPK Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Publications

Product: Raingeaud, Gupta, Rogers et al.: "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine." in: The Journal of biological chemistry, Vol. 270, Issue 13, pp. 7420-6, 1995 (PubMed).

Han, Richter, Li et al.: "Molecular cloning of human p38 MAP kinase." in: Biochimica et biophysica acta, Vol. 1265, Issue 2-3, pp. 224-7, 1995 (PubMed).

Han, Lee, Bibbs et al.: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994 (PubMed).