Mitogen-Activated Protein Kinase 14 (MAPK14) antibody

Details for Product No. ABIN650180
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Antigen
Synonyms
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csb ... show more
P38C-CRK, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CRK1, Csbp1, Csbp2, Exip, Hog, Prkm14, Prkm15, Sapk2A, p38Hog, p38alpha, Crk1, p38-alpha, p38MAPK, p38a, csbp, mapk14a, mxi2, sapk2, sapk2a, p38b, zp38b, MAPK14, 186F5S, BG:DS00797.3, CG7393, D-p38, D-p38 MAPK, D-p38b, Dm p38b, Dmel\\CG7393, Dmp38b, Dp38, Dp38b, ESTS:186F5S, Mpk34C, anon-sts23, dp38b, p38 MAPK, p38 beta, p38B, p38Kb, p38beta show less
Reactivity
Human, Rat (Rattus)
(312), (219), (214), (77), (48), (41), (15), (10), (6), (6), (5), (5), (5), (2), (1), (1), (1)
Host
Rabbit
(287), (37), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(257), (113), (85), (53), (50), (45), (22), (19), (9), (9), (8), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN650180
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to residues near the C-terminus of human p38 MAP kinase was used as immunogen. Predicted to react with CSBP1 splice form based on sequence homology.
Specificity A synthetic peptide corresponding to residues near the C-terminus of human p38 MAP kinase was used as immunogen. Predicted to react with CSBP1 splice form based on sequence homology.
Alternative Name p38 MAPK
Background P38 MAP kinase is a mitogen-activated protein kinase that functions in various intracellular signaling cascades controlling cellular stress responses. p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-3). MKK3 and SEK activate p38 MAP kinase by phosphorylation at adjacent threonine and tyrosine residues, Thr180 and Tyr182 (3,4). Activated p38 MAP kinase phosphorylates numerous downstream targets, including transcription factor ATF-2 (4).
Synonyms: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, Mitogen-activated protein kinase 14, MAX-interacting protein 2,MAP kinase MXI2,SAPK2A
Molecular Weight 42 kDA
Gene ID 1432
UniProt Q16539
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:100-250
Comment

Background: p38 MAP kinase is a mitogen-activated protein kinase that functions in various intracellular signaling cascades controlling cellular stress responses. p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (1-3). MKK3 and SEK activate p38 MAP kinase by phosphorylation at adjacent threonine and tyrosine residues, Thr180 and Tyr182 (3,4). Activated p38 MAP kinase phosphorylates numerous downstream targets, including transcription factor ATF-2 (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment p38 MAPK Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Raingeaud, Gupta, Rogers et al.: "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine." in: The Journal of biological chemistry, Vol. 270, Issue 13, pp. 7420-6, 1995 (PubMed).

Han, Richter, Li et al.: "Molecular cloning of human p38 MAP kinase." in: Biochimica et biophysica acta, Vol. 1265, Issue 2-3, pp. 224-7, 1995 (PubMed).

Han, Lee, Bibbs et al.: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994 (PubMed).

Hosts (287), (37), (2), (1)
Reactivities (312), (219), (214), (77), (48), (41), (15), (10), (6), (6), (5), (5), (5), (2), (1), (1), (1)
Applications (257), (113), (85), (53), (50), (45), (22), (19), (9), (9), (8), (3), (3), (2), (2), (1), (1), (1), (1)
Conjugates (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (89), (74), (18), (16), (16), (13), (13), (9), (6), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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