anti-p53 antibody (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN650183
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Antigen
Reactivity
Human, Rat (Rattus)
(1869), (351), (280), (51), (27), (12), (12), (11), (8), (7), (6), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1)
Host
Rabbit
(1311), (658), (8), (6), (3), (1), (1)
Clonality
Monoclonal
Conjugate
This p53 antibody is un-conjugated
(58), (51), (33), (32), (24), (24), (17), (16), (16), (16), (16), (16), (16), (16), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(1496), (651), (558), (387), (385), (327), (241), (162), (134), (88), (54), (34), (30), (28), (19), (19), (18), (16), (13), (7), (7), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μL
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Immunogen A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.
Specificity A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.
Alternative Name p53 (TP53 Antibody Abstract)
Background P53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).
Synonyms: TP53, P53, Cellular tumor antigen p53, Tumor suppressor p53,Phosphoprotein p53,Antigen NY-CO-13
Molecular Weight 53 kDA
Gene ID 7157
UniProt P04637
Research Area Translation Factors, Protein Modifications, Signaling, Cell Structure, Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cancer, Transcription Factors
Pathways p53 Pathway, PI3K-Akt Signaling Pathway
Application Notes The suggested dilution is: WB: = 1:10000-50000,IHC: = 1:100
Comment

Background: p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment p53 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lakin, Jackson: "Regulation of p53 in response to DNA damage." in: Oncogene, Vol. 18, Issue 53, pp. 7644-55, 2000 (PubMed).

Levine: "p53, the cellular gatekeeper for growth and division." in: Cell, Vol. 88, Issue 3, pp. 323-31, 1997 (PubMed).

Harris: "p53: at the crossroads of molecular carcinogenesis and risk assessment." in: Science (New York, N.Y.), Vol. 262, Issue 5142, pp. 1980-1, 1994 (PubMed).

Vogelstein: "Cancer. A deadly inheritance." in: Nature, Vol. 348, Issue 6303, pp. 681-2, 1991 (PubMed).

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Catalog No. ABIN650183
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