|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Tumor Protein P53 (TP53) antibody
|Synonyms||p53, LFS1, TRP53, FLJ92943, P53, Trp53, MGC112612, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919, TP53, bbl, bfy, bhy, p44, Tp53, tp53|
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
|4 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.|
|Description||Other names: TP53, P53, Cellular tumor antigen p53, Tumor suppressor p53,Phosphoprotein p53,Antigen NY-CO-13|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.|
|Molecular Weight||53 kDA|
Background: p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).
|Application Notes||The suggested dilution is: WB: ~~ 1:10000~50000 ICC: ~~ 1:50~100 IHC: ~~ 1:100|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||p53 Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Translation Factors, Protein Modifications, Signaling, Cell Structure, Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cancer, Transcription Factors|
|Restrictions||For Research Use only|
Vogelstein: "Cancer. A deadly inheritance." in: Nature, Vol. 348, Issue 6303, pp. 681-2, 1991 (PubMed).
Harris: "p53: at the crossroads of molecular carcinogenesis and risk assessment." in: Science (New York, N.Y.), Vol. 262, Issue 5142, pp. 1980-1, 1994 (PubMed).
Levine: "p53, the cellular gatekeeper for growth and division." in: Cell, Vol. 88, Issue 3, pp. 323-31, 1997 (PubMed).
Lakin, Jackson: "Regulation of p53 in response to DNA damage." in: Oncogene, Vol. 18, Issue 53, pp. 7644-55, 2000 (PubMed).