Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN650191

Tumor Protein P53 (TP53) (pSer46) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms BCC7, LFS1, P53, TRP53, p53, Trp53, bbl, bfy, bhy, p44, Tp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919, tp53
Epitope
»Alternatives pSer46
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN650191
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen A synthetic phospho-peptide corresponding to residues surrounding serine 46 of human p53 protein.
Specificity A synthetic phospho-peptide corresponding to residues surrounding serine 46 of human p53 protein.
Alternative Name p53
Background P53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. Due to UV-induced DNA damage, p53 is phosphorylated on eight different serine/threonine locations on the N-terminal. Phospholyation on serine 46 has been implicated as a mediator in apoptosis induced by DNA-damage (4, 5).
Synonyms: TP53, P53, Cellular tumor antigen p53, Tumor suppressor p53,Phosphoprotein p53,Antigen NY-CO-13
Molecular Weight 53 kDA
Gene ID 7157
UniProt P04637
Research Area Translation Factors, Protein Modifications, Signaling, Cell Structure, Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cancer, Transcription Factors
Application Notes The suggested dilution is: WB: ~~ 1:20000 IP: ~~ 1:40 ICC: ~~ 1:50 IHC: ~~ 1:100~250
Comment

Background: p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers. Due to UV-induced DNA damage, p53 is phosphorylated on eight different serine/threonine locations on the N-terminal. Phospholyation on serine 46 has been implicated as a mediator in apoptosis induced by DNA-damage (4, 5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment p53 Antibody Phospho (pS46) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lakin, Jackson: "Regulation of p53 in response to DNA damage." in: Oncogene, Vol. 18, Issue 53, pp. 7644-55, 2000 (PubMed).

Alternatives for antigen "Tumor Protein P53 (TP53)", type "Antibodies"
Hosts (859), (442), (5), (3), (2), (2), (1)
Reactivities (1223), (289), (238), (86), (80), (67), (32), (25), (16), (11), (8), (8), (8), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1)
Applications (947), (438), (376), (264), (262), (193), (160), (143), (90), (76), (22), (16), (9), (7), (6), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Conjugates (37), (29), (19), (16), (16), (16), (16), (16), (16), (16), (16), (4), (3), (3), (2), (1), (1)
Epitopes (49), (42), (40), (39), (38), (36), (35), (35), (33), (33), (30), (30), (26), (21), (17), (17), (15), (9), (8), (7), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon