Tumor Protein P63 (TP63) (C-Term) antibody

Details for Product No. ABIN650196
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Antigen
Synonyms
DNp63, id:ibd3516, p63, tp73l, wu:fc89f04, wu:fk85h07, wu:fk88b02, AIS, KET, LMS, NBP, RHS, p40, p51, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), TRP63, Xp63, ket, np ... show more
DNp63, id:ibd3516, p63, tp73l, wu:fc89f04, wu:fk85h07, wu:fk88b02, AIS, KET, LMS, NBP, RHS, p40, p51, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B), TRP63, Xp63, ket, np63, tp73l-A, trp63, AI462811, Ket, P51/P63, P63, P73l, Tp63, Trp53rp1, AI528772, CCT, Cct1, Ccta, TRic, Tcp-1, c-cpn, TP63, tp63 show less
Epitope
C-Term
(13), (4), (3), (2), (2), (1)
Reactivity
Human
(36), (27), (25), (4), (4), (4), (4), (2), (2), (1)
Host
Rabbit
(31), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(29), (15), (10), (9), (8), (5), (4), (1)
Pubmed 3 references available
Catalog no. ABIN650196
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to residues to the C-term of human p63 (p73L) was used as immunogen. This antibody should detect both isoforms 2,9,10,11 and 12.
Specificity A synthetic peptide corresponding to residues to the C-term of human p63 (p73L) was used as immunogen. This antibody should detect both isoforms 2,9,10,11 and 12.
Alternative Name p63 (p73L)
Background P63 (also called KET, p51, p40, AIS, and p73L) (1) is a transcription factor that shares a significant amino acid identity with p53 and p73. p63 and p73 can both activate p53-responsive genes and induce apoptosis upon over- expression (2). p63 has an additional coding region in the C-termini (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (α,, Beta, and γ,) (3). Additionally, two isoforms can be found, one containing the N-terminal transactivating domain (TA) or the (Δ,N) lacking TA (2). p63 plays a more fundamental role associated with development and differentiation. Mutations in p63, although not as common as p53, may result in the ADULT, AEC and ECC3 syndrome (4-5).
Synonyms: TP63, KET, P63, P73H, P73L, TP73L, Tumor protein 63, p51,p40,Keratinocyte transcription factor KET,Chronic ulcerative stomatitis protein
Molecular Weight 63 kDA
Gene ID 8626
UniProt Q9H3D4
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:2000
Comment

Background: p63 (also called KET, p51, p40, AIS, and p73L) (1) is a transcription factor that shares a significant amino acid identity with p53 and p73. p63 and p73 can both activate p53-responsive genes and induce apoptosis upon over- expression (2). p63 has an additional coding region in the C-termini (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (α,, β,, and γ,) (3). Additionally, two isoforms can be found, one containing the N-terminal transactivating domain (TA) or the (Δ,N) lacking TA (2). p63 plays a more fundamental role associated with development and differentiation. Mutations in p63, although not as common as p53, may result in the ADULT, AEC and ECC3 syndrome (4-5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment p63 (p73L) Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Schmale, Bamberger: "A novel protein with strong homology to the tumor suppressor p53." in: Oncogene, Vol. 15, Issue 11, pp. 1363-7, 1997 (PubMed).

Yang, Kaghad, Wang et al.: "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities." in: Molecular cell, Vol. 2, Issue 3, pp. 305-16, 1998 (PubMed).

Akahoshi, Sakazume, Kosaki et al.: "EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma." in: American journal of medical genetics. Part A, Vol. 120A, Issue 3, pp. 370-3, 2003 (PubMed).

Hosts (31), (7)
Reactivities (36), (27), (25), (4), (4), (4), (4), (2), (2), (1)
Applications (29), (15), (10), (9), (8), (5), (4), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (4), (3), (2), (2), (1)
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