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Background: Poly (A)-binding protein II (PABP2) is an abundant nuclear protein that binds with high affinity to nascent poly (A) tails, stimulating their extension and controlling their length. PABP2 is reported to interact with the nuclear export machinery and may therefore contribute to mRNA transport (1). PABP2 stimulates extension of the growing poly (A) tail during the polyadenylation process, and limits the length of the newly synthesized poly (A) tail (2). PABP2 is reported to be detected in filamentous nuclear inclusions, which are the pathological hallmark of oculopharyngeal muscular dystrophy. This suggests that the polyalanine expansions in PABP2 induce a misfolding and aggregation of the protein into insoluble inclusions, similarly to events in neurodegenerative diseases caused by CAG/polyglutamine expansions (3).