Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) antibody

Details for Product No. ABIN650203
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Antigen
Synonyms PABP2, PABP4, PABPCP2, PABPCP4, OPMD, PAB2, PABII, PABP-2
Reactivity
Human
(4)
Host
Rabbit
(3), (1)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(4), (2), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN650203
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human PABP2 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human PABP2 was used as an immunogen.
Alternative Name PABP2
Background Poly (A)-binding protein II (PABP2) is an abundant nuclear protein that binds with high affinity to nascent poly (A) tails, stimulating their extension and controlling their length. PABP2 is reported to interact with the nuclear export machinery and may therefore contribute to mRNA transport (1). PABP2 stimulates extension of the growing poly (A) tail during the polyadenylation process, and limits the length of the newly synthesized poly (A) tail (2). PABP2 is reported to be detected in filamentous nuclear inclusions, which are the pathological hallmark of oculopharyngeal muscular dystrophy. This suggests that the polyalanine expansions in PABP2 induce a misfolding and aggregation of the protein into insoluble inclusions, similarly to events in neurodegenerative diseases caused by CAG/polyglutamine expansions (3).
Synonyms: PABPN1, PAB2, PABP2, Polyadenylate-binding protein 2, Polyadenylate-binding nuclear protein 1,Nuclear poly(A)-binding protein 1
Molecular Weight 49 kDA
Gene ID 8106
UniProt Q86U42
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1: 1000-10000 , IHC: = 1:100-250
Comment

Background: Poly (A)-binding protein II (PABP2) is an abundant nuclear protein that binds with high affinity to nascent poly (A) tails, stimulating their extension and controlling their length. PABP2 is reported to interact with the nuclear export machinery and may therefore contribute to mRNA transport (1). PABP2 stimulates extension of the growing poly (A) tail during the polyadenylation process, and limits the length of the newly synthesized poly (A) tail (2). PABP2 is reported to be detected in filamentous nuclear inclusions, which are the pathological hallmark of oculopharyngeal muscular dystrophy. This suggests that the polyalanine expansions in PABP2 induce a misfolding and aggregation of the protein into insoluble inclusions, similarly to events in neurodegenerative diseases caused by CAG/polyglutamine expansions (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment PABP2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Calado, Kutay, Kühn et al.: "Deciphering the cellular pathway for transport of poly(A)-binding protein II." in: RNA (New York, N.Y.), Vol. 6, Issue 2, pp. 245-56, 2000 (PubMed).

Calado, Tomé, Brais et al.: "Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA." in: Human molecular genetics, Vol. 9, Issue 15, pp. 2321-8, 2000 (PubMed).

Kim, Noguchi, Hayashi et al.: "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression." in: Human molecular genetics, Vol. 10, Issue 11, pp. 1129-39, 2001 (PubMed).

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