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Retinoblastoma Binding Protein 6 (RBBP6) (C-Term) antibody

Details for Product No. ABIN650204
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Antigen
Synonyms rbbp6, MGC75882, RBBP6, DYT16, PACT, RAX, MY038, P2P-R, RBQ-1, SNAMA, 4933422O15Rik, AI316869, BB233631, C030034J04Rik, C77662
Epitope
C-Term
(7), (5), (5), (3), (2), (2), (1)
Reactivity
Human, Rat (Rattus)
(62), (41), (37), (12), (12), (12), (12)
Host
Rabbit
(51), (12)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(35), (21), (20), (10), (10), (8), (5), (2)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN650204
450.00 $
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Immunogen A synthetic peptide corresponding to residues on the C terminus of human PACT was used as an immunogen.
Specificity A synthetic peptide corresponding to residues on the C terminus of human PACT was used as an immunogen.
Alternative Name PACT
Background Protein kinase, interferon-inducible double stranded RNA dependent activator (PACT, PRKRA) is a proapoptotic cellular protein activator of PKR, a double-stranded RNA-dependent protein kinase (1). PACT is reported to be stress-activated, and a physiologic activator that couples transmembrane stress signals and protein synthesis (2). Overexpression of PACT in cells causes enhanced sensitivity to stress-induced apoptosis. It is expressed at high levels in colonic epithelial cells, especially as they exit the cell cycle and enter an apoptotic program (3).
Synonyms: PRKRA, PACT, RAX, Interferon-inducible double stranded RNA-dependent protein kinase activator A, Protein kinase, interferon-inducible double stranded RNA-dependent activator,Protein activator of the interferon-induced protein kinase,PKR-associated protein
Molecular Weight 35 kDA
Gene ID 8575
UniProt O75569
Research Area Phospho-specific antibodies, Protein Modifications, Signaling, Chromatin, Neurology, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-5000
Comment

Background: Protein kinase, interferon-inducible double stranded RNA dependent activator (PACT, PRKRA) is a proapoptotic cellular protein activator of PKR, a double-stranded RNA-dependent protein kinase (1). PACT is reported to be stress-activated, and a physiologic activator that couples transmembrane stress signals and protein synthesis (2). Overexpression of PACT in cells causes enhanced sensitivity to stress-induced apoptosis. It is expressed at high levels in colonic epithelial cells, especially as they exit the cell cycle and enter an apoptotic program (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment PACT Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Patel, Sen: "PACT, a protein activator of the interferon-induced protein kinase, PKR." in: The EMBO journal, Vol. 17, Issue 15, pp. 4379-90, 1998 (PubMed).

Ito, Yang, May: "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15427-32, 1999 (PubMed).

Validation Images
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