Paired Box 2 (PAX2) antibody

Details for Product No. ABIN650221
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms PAPRS, PAX-2, PAX2
Reactivity
Human
(52), (24), (17), (14), (13), (13), (13), (1), (1), (1), (1), (1)
Host
Rabbit
(51), (7), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(41), (21), (13), (10), (8), (4), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN650221
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.
Alternative Name PAX2
Background PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).
Molecular Weight 46 kDA
Gene ID 5076
UniProt Q02962
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes IHC: = 1:1000-2500, WB: = 1:1000-10000
Comment

Background: PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment PAX2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hurtado, Holmes, Geistlinger et al.: "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen." in: Nature, Vol. 456, Issue 7222, pp. 663-6, 2008 (PubMed).

Hosts (51), (7), (1)
Reactivities (52), (24), (17), (14), (13), (13), (13), (1), (1), (1), (1), (1)
Applications (41), (21), (13), (10), (8), (4), (4), (2), (2), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
back to top