Paired Box 2 (PAX2) antibody

Antigen: Paired Box 2 (PAX2)

Synonyms: Pax-2, PAX2

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Certificates: ISO 9001:2008

Catalog no.: ABIN650221

Additional Information

Alternative name: PAX2

Gene ID: 5076

UniProt: Q02962

Immunogen: A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.

Molecular Weight: 46 kDA

Comments:

Background: PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 FC: ~~ 1:50 IHC: ~~ 1:1000~2500

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: PAX2 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Hurtado, Holmes, Geistlinger et al.: "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen." in: Nature, Vol. 456, Issue 7222, pp. 663-6, 2008 (PubMed).