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Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) antibody

Details for Product No. ABIN650231
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Antigen
Synonyms H731, Ma3, Tis, D19Ucla1, Dug, h731, MGC69337, PDCD4
Reactivity
Human
(146), (85), (85), (11), (6), (3), (3), (2), (1)
Host
Rabbit
(117), (25), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(125), (88), (52), (34), (12), (10), (8), (5), (3), (3), (2)
Pubmed 2 references available
Quantity 100 µL
Options
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN650231
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues near the C-terminus of human PDCD4 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues near the C-terminus of human PDCD4 was used as an immunogen.
Alternative Name PDCD4
Background Programmed cell death protein 4 (PDCD4) is a tumor suppressor that inhibits tumor promoter-induced neoplastic transformation. It down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription (1). PDCD4 inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5', untranslated region (5',UTR) of messenger RNAs (mRNAs). It is also believed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis and consequently cell growth (2).
Synonyms: PDCD4, H731, Programmed cell death protein 4, Nuclear antigen H731-like,Neoplastic transformation inhibitor protein,Protein 197/15a
Molecular Weight 54 kDA
Gene ID 27250
UniProt Q53EL6
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Cancer, Signaling, Chromatin, Cell Structure
Application Notes IHC: = 1:1000-2000, WB: = 1:500-1000
Comment

Background: Programmed cell death protein 4 (PDCD4) is a tumor suppressor that inhibits tumor promoter-induced neoplastic transformation. It down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription (1). PDCD4 inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of secondary structure at the 5', untranslated region (5',UTR) of messenger RNAs (mRNAs). It is also believed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis and consequently cell growth (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment PDCD4 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Dorrello, Peschiaroli, Guardavaccaro et al.: "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth." in: Science (New York, N.Y.), Vol. 314, Issue 5798, pp. 467-71, 2006 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Hosts (117), (25), (4)
Reactivities (146), (85), (85), (11), (6), (3), (3), (2), (1)
Applications (125), (88), (52), (34), (12), (10), (8), (5), (3), (3), (2)
Conjugates (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (23), (11), (11), (10), (7), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650231
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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