Peroxiredoxin 6 (PRDX6) antibody

Antigen: Peroxiredoxin 6 (PRDX6)

Synonyms: PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, KIAA0106, MGC46173, GPx, Aop2, CP-3, Ltw4, Ltw-4, ORF06, Prdx5, Brp-12, Lvtw-4, 1-cysPrx, AA690119, Aop2-rs3, Prdx6-rs3, mKIAA0106, 9430088D19Rik, AOPP, PrxV, Pmp20, Prdx6, AOEB166, PRDX6, MGC73360, zgc:73360, aop2, prx6, MGC76137, MGC64582, prdx6, MGC64522

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Certificates: ISO 9001:2008

Catalog no.: ABIN650242

Additional Information

Alternative name: Peroxiredoxin-6

Gene ID: 5350

UniProt: P30041

Immunogen: A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.

Characteristics: Rabbit Monoclonal

Specificity: A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.

Molecular Weight: 25 kDA

Comments:

Background: Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation, differentiation, and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs, with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically, Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2).

Synonyms: PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, KIAA0106, MGC46173, GPx, Aop2, CP-3, Ltw4, Ltw-4, ORF06, Prdx5, Brp-12, Lvtw-4, 1-cysPrx, AA690119, Aop2-rs3, Prdx6-rs3, mKIAA0106, 9430088D19Rik, AOPP, PrxV, Pmp20, Prdx6, AOEB166, PRDX6, MGC73360, zgc:73360, aop2, prx6, MGC76137, MGC64582, prdx6, MGC64522

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~5000 IP: ~~ 1:10 FC: ~~ 1:60 ICC: ~~ 1:100~250 IHC: ~~ 1:250~500

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Wood, Schröder, Robin Harris et al.: "Structure, mechanism and regulation of peroxiredoxins." in: Trends in biochemical sciences, Vol. 28, Issue 1, pp. 32-40, 2003 (PubMed).

Manevich, Fisher: "Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism." in: Free radical biology & medicine, Vol. 38, Issue 11, pp. 1422-32, 2005 (PubMed).