Peroxiredoxin 6 (PRDX6) antibody

Details for Product No. ABIN650242
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Antigen
Synonyms
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, ... show more
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, prx-6, prx6, prdx6, MGC64522 show less
Reactivity
Human, Rat (Rattus)
(72), (26), (20), (4), (4), (2), (2), (2), (1)
Host
Rabbit
(49), (32), (2), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(77), (55), (28), (25), (14), (13), (10), (7), (4), (4)
Pubmed 2 references available
Catalog no. ABIN650242
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues of human Peroxiredoxin 6 was used as an immunogen.
Alternative Name Peroxiredoxin-6
Background Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation, differentiation, and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs, with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically, Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2).
Molecular Weight 25 kDA
Gene ID 5350
UniProt P30041
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:1000-5000
Comment

Background: Peroxiredoxins (Prx) are a family of ubiquitous antioxidant enzymes which regulates cytokine-induced peroxide levels and mediates signal transduction in various mammalian cells. Prx family members have been linked to cell proliferation, differentiation, and apoptosis (1). Peroxiredoxin 6 (Prdx6) is only mammalian 1-Cys member of the peroxiredoxin family and it is expressed in all major organs, with particularly high expression in lung. Prdx6 is considered antioxidant enzyme and has a major role in lung phospholipid metabolism. Specifically, Prdx6 might be involved in antioxidant defense by facilitating repair of damaged cell membranes via reduction of peroxidized phospholipids and alterations of lung surfactant phospholipid synthesis and turnover (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Wood, Schröder, Robin Harris et al.: "Structure, mechanism and regulation of peroxiredoxins." in: Trends in biochemical sciences, Vol. 28, Issue 1, pp. 32-40, 2003 (PubMed).

Manevich, Fisher: "Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism." in: Free radical biology & medicine, Vol. 38, Issue 11, pp. 1422-32, 2005 (PubMed).

Hosts (49), (32), (2), (2)
Reactivities (72), (26), (20), (4), (4), (2), (2), (2), (1)
Applications (77), (55), (28), (25), (14), (13), (10), (7), (4), (4)
Conjugates (4), (2)
Epitopes (6), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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