Peroxiredoxin 6 (PRDX6) antibody

Details for Product No. ABIN650243
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Antigen
Synonyms
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, ... show more
1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX, aop2, prx-6, prx6, prdx6, MGC64522 show less
Reactivity
Human, Rat (Rattus)
(72), (26), (20), (4), (4), (2), (2), (2), (1)
Host
Rabbit
(49), (32), (2), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(77), (55), (28), (25), (14), (13), (9), (7), (4), (4)
Pubmed 3 references available
Catalog no. ABIN650243
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.
Alternative Name Peroxiredoxin-6
Background Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).
Molecular Weight 25 kDA
Gene ID 7113
UniProt P30041
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:100-250
Comment

Background: Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kümin, Huber, Rülicke et al.: "Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis." in: The American journal of pathology, Vol. 169, Issue 4, pp. 1194-205, 2006 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Roede, Orlicky, Fisher et al.: "Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation." in: The Journal of pharmacology and experimental therapeutics, Vol. 330, Issue 1, pp. 79-88, 2009 (PubMed).

Hosts (49), (32), (2), (2)
Reactivities (72), (26), (20), (4), (4), (2), (2), (2), (1)
Applications (77), (55), (28), (25), (14), (13), (9), (7), (4), (4)
Conjugates (4), (2)
Epitopes (6), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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