Peroxiredoxin 6 (PRDX6) antibody

Details for Product No. ABIN650243
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Antigen
Synonyms
aop2, prx-6, prx6, prdx6, AOEB166, AOPP, Pmp20, Prdx6, PrxV, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP ... show more
aop2, prx-6, prx6, prdx6, AOEB166, AOPP, Pmp20, Prdx6, PrxV, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Aop2-rs3, Brp-12, CC26, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGP, ORF06, Prdx5, Prdx6-rs3, mKIAA0106, zgc:73360, PHGPX show less
Reactivity
Human, Rat (Rattus)
(83), (27), (19), (4), (4), (2), (2), (2), (1)
Host
Rabbit
(54), (33), (3), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (3), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(82), (56), (33), (28), (16), (13), (13), (12), (5), (4), (3)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN650243
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.
Alternative Name Peroxiredoxin-6
Background Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).
Molecular Weight 25 kDA
Gene ID 7113
UniProt P30041
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-10000 , IHC: = 1:100-250
Comment

Background: Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kümin, Huber, Rülicke et al.: "Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis." in: The American journal of pathology, Vol. 169, Issue 4, pp. 1194-205, 2006 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Roede, Orlicky, Fisher et al.: "Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation." in: The Journal of pharmacology and experimental therapeutics, Vol. 330, Issue 1, pp. 79-88, 2009 (PubMed).

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