|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Peroxiredoxin 6 (PRDX6) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
|3 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.|
|Molecular Weight||25 kDA|
Background: Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).
|Synonyms||PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, KIAA0106, MGC46173, GPx, Aop2, CP-3, Ltw4, Ltw-4, ORF06, Prdx5, Brp-12, Lvtw-4, 1-cysPrx, AA690119, Aop2-rs3, Prdx6-rs3, mKIAA0106, 9430088D19Rik, AOPP, PrxV, Pmp20, Prdx6, AOEB166, PRDX6, MGC73360, zgc:73360, aop2, prx6, MGC76137, MGC64582, prdx6, MGC64522|
|Application Notes||The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:10~100 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure|
|Restrictions||For Research Use only|
Kümin, Huber, Rülicke et al.: "Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis." in: The American journal of pathology, Vol. 169, Issue 4, pp. 1194-205, 2006 (PubMed).
Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).
Roede, Orlicky, Fisher et al.: "Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation." in: The Journal of pharmacology and experimental therapeutics, Vol. 330, Issue 1, pp. 79-88, 2009 (PubMed).
|Hosts||Rabbit (25), Mouse (14), Sheep (1)|
|Reactivities||Human (32), Rat (Rattus) (14), Mouse (Murine) (9), Chicken (2), Cow (Bovine) (2), Pig (Porcine) (2), Xenopus laevis (2), Zebrafish (1)|
|Applications||Western Blotting (WB) (36), ELISA (30), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunocytochemistry (ICC) (5), Immunofluorescence (IF) (5), Immunoprecipitation (IP) (4), Flow Cytometry (FACS) (3)|
|Conjugates||Biotin (2), FITC (1)|
|Epitopes||C-Term (2), Center (1), Internal Region (1)|