Peroxiredoxin 6 (PRDX6) antibody

Antigen: Peroxiredoxin 6 (PRDX6)

Synonyms: PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, KIAA0106, MGC46173, GPx, Aop2, CP-3, Ltw4, Ltw-4, ORF06, Prdx5, Brp-12, Lvtw-4, 1-cysPrx, AA690119, Aop2-rs3, Prdx6-rs3, mKIAA0106, 9430088D19Rik, AOPP, PrxV, Pmp20, Prdx6, AOEB166, PRDX6, MGC73360, zgc:73360, aop2, prx6, MGC76137, MGC64582, prdx6, MGC64522

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN650243

Additional Information

Alternative name: Peroxiredoxin-6

Gene ID: 7113

UniProt: P30041

Immunogen: A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human Peroxiredoxin 6 was used as an immunogen.

Molecular Weight: 25 kDA

Comments:

Background: Peroxiredoxin 6, a member of the thiol-specific antioxidant protein family (1), is an enzyme that detoxifies hydrogen peroxide and various organic peroxides (2). It is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults (3). Peroxiredoxin 6 has two distinct active sites, and is involved in redox regulation of the cell, it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (1). Peroxiredoxin 6 has been hypothesized to also protect the liver from oxidative stress generated during the process of chronic ethanol ingestion (3), and may play a role in the regulation of phospholipid turnover (1).

Synonyms: PRX, p29, AOP2, 1-Cys, NSGPx, aiPLA2, KIAA0106, MGC46173, GPx, Aop2, CP-3, Ltw4, Ltw-4, ORF06, Prdx5, Brp-12, Lvtw-4, 1-cysPrx, AA690119, Aop2-rs3, Prdx6-rs3, mKIAA0106, 9430088D19Rik, AOPP, PrxV, Pmp20, Prdx6, AOEB166, PRDX6, MGC73360, zgc:73360, aop2, prx6, MGC76137, MGC64582, prdx6, MGC64522

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:10~100 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Peroxiredoxin-6 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Kümin, Huber, Rülicke et al.: "Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis." in: The American journal of pathology, Vol. 169, Issue 4, pp. 1194-205, 2006 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Roede, Orlicky, Fisher et al.: "Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation." in: The Journal of pharmacology and experimental therapeutics, Vol. 330, Issue 1, pp. 79-88, 2009 (PubMed).