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Details for Product No. ABIN650312

Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) antibody

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Antigen
Synonyms PP2A, PR53, PTPA, PTPRA
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN650312
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen A synthetic peptide corresponding to residues near C-terminus of human PP2A was used as immunogen. This antibody detects both alpha and beta isoforms of PP2A.
Specificity A synthetic peptide corresponding to residues near C-terminus of human PP2A was used as immunogen. This antibody detects both alpha and beta isoforms of PP2A.
Alternative Name PP2A
Background Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4).
Synonyms: PPP2CA, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C
Molecular Weight 36 kDA
Gene ID 5515
UniProt P67775
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Chromatin, Metabolism, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:5000 IP: ~~ 1:100 ICC: ~~ 1:50 IHC: ~~ 1:250~500
Comment

Background: Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment PP2A Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Janssens, Goris: "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling." in: The Biochemical journal, Vol. 353, Issue Pt 3, pp. 417-39, 2001 (PubMed).

Alternatives for antigen "Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4)", type "Antibodies"
Hosts (22), (10), (6)
Reactivities (33), (12), (11), (3), (2), (1), (1), (1), (1), (1), (1)
Applications (35), (12), (11), (7), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Conjugates (1), (1)
Epitopes (7), (4), (3), (1), (1), (1), (1), (1)
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