Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) (N-Term) antibody

Details for Product No. ABIN650313
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Antigen
Synonyms 6330556D22Rik, PP2A, PR65, PR53, PTPA, PTPRA, 2610042B21Rik, C77440, N28142
Epitope
N-Term
(11), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(43), (16), (14), (3), (1), (1), (1)
Host
Rabbit
(28), (12), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(44), (18), (16), (10), (7), (6), (5), (4), (2), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN650313
450.00 $
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Immunogen A synthetic peptide corresponding to residues in N-terminus of human PP2A-alpha was used as immunogen. Predicted to cross-react with bovin and pig, based on sequence homology.
Specificity A synthetic peptide corresponding to residues in N-terminus of human PP2A-alpha was used as immunogen. Predicted to cross-react with bovin and pig, based on sequence homology.
Alternative Name PP2A
Background Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4).
Synonyms: PPP2CA, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C
Molecular Weight 36 kDA
Gene ID 5515
UniProt P67775
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Chromatin, Metabolism, Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:500
Comment

Background: Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment PP2A Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Janssens, Goris: "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling." in: The Biochemical journal, Vol. 353, Issue Pt 3, pp. 417-39, 2001 (PubMed).

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