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RAD17 Homolog (S. Pombe) (RAD17) (pSer656) antibody

Details for Product No. ABIN650360
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Antigen
Synonyms CCYC, HRAD17, R24L, RAD17SP, RAD24, 9430035O09Rik, MmRad24, K2A18.21, K2A18_21, RAD17, RADIATION SENSITIVE 17, zgc:56502, zgc:77779, xrad1, RAD1, DKFZp459H1127, zgc:91969
Epitope
pSer656
(23), (8), (7), (6), (5), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(106), (51), (36), (13), (13), (12), (3), (2), (1), (1)
Host
Rabbit
(98), (15), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(102), (44), (20), (20), (11), (11), (8), (3), (3), (3), (2), (1)
Pubmed 2 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN650360
507.14 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A phospho-specific peptide corresponding to residues in human Rad17 was used as an immunogen. The antibody only detects Rad17 phosphoryated on Serine 656.
Specificity A phospho-specific peptide corresponding to residues in human Rad17 was used as an immunogen. The antibody only detects Rad17 phosphoryated on Serine 656.
Alternative Name RAD17
Background Checkpoint Rad proteins function early in the DNA damage signaling cascade to arrest cell cycle progression in response to DNA damage (1). There is a direct regulatory linkage between Rad17 and the checkpoint kinases, ATM and ATR (2). Rad17 has been reported to be a phosphorylation substrate of ATR and is critical for ATR-mediated checkpoint signaling and cell survival. Phosphorylation of Rad17 by ATR is important for genomic stability and restraint of S phase but is not essential for cell survival (3).
Synonyms: RAD17, R24L, Cell cycle checkpoint protein RAD17, RF-C/activator 1 homolog
Molecular Weight 80 kDA
Gene ID 5884
UniProt O75714
Research Area Phospho-specific antibodies, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:5000-10000 , IHC: = 1:100-250
Comment

Background: Checkpoint Rad proteins function early in the DNA damage signaling cascade to arrest cell cycle progression in response to DNA damage (1). There is a direct regulatory linkage between Rad17 and the checkpoint kinases, ATM and ATR (2). Rad17 has been reported to be a phosphorylation substrate of ATR and is critical for ATR-mediated checkpoint signaling and cell survival. Phosphorylation of Rad17 by ATR is important for genomic stability and restraint of S phase but is not essential for cell survival (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Rad17 Antibody Phospho (pS656) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Bao, Tibbetts, Brumbaugh et al.: "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses." in: Nature, Vol. 411, Issue 6840, pp. 969-74, 2001 (PubMed).

Lindsey-Boltz, Bermudez, Hurwitz et al.: "Purification and characterization of human DNA damage checkpoint Rad complexes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11236-41, 2001 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650360
507.14 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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