anti-Radixin antibody (RDX) (N-Term)

Details for Product anti-RDX Antibody No. ABIN650361
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Antigen
Epitope
N-Term
(18), (17), (15), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(99), (42), (38), (5), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(64), (23), (14)
Clonality
Monoclonal
Conjugate
This Radixin antibody is un-conjugated
(6), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(87), (58), (10), (10), (10), (9), (3), (3), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Immunogen A synthetic peptide corresponding to residues near the N-terminus of human Radixin was used as an immunogen.
Specificity A synthetic peptide corresponding to residues near the N-terminus of human Radixin was used as an immunogen.
Alternative Name Radixin (RDX Antibody Abstract)
Background Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).
Synonyms: RDX, Radixin
Molecular Weight 80 kDA
Gene ID 5962
UniProt P35241
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-5000
Comment

Background: Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Radixin Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kikuchi, Hata, Fukumoto et al.: "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes." in: Nature genetics, Vol. 31, Issue 3, pp. 320-5, 2002 (PubMed).

Wilgenbus, Milatovich, Francke et al.: "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes." in: Genomics, Vol. 16, Issue 1, pp. 199-206, 1993 (PubMed).

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Catalog No. ABIN650361
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