Retinoblastoma 1 (RB1) antibody

Details for Product No. ABIN650375
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Antigen
Synonyms RB, pRb, OSRC, pp110, p105-Rb, Rb, Rb-1, P105-RB, PP110, RB11, zgc:154147, RB1
Reactivity
Human
(332), (218), (204), (109), (85), (70), (48), (1), (1), (1)
Host
Rabbit
(287), (56), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Western Blotting (WB)
(209), (100), (94), (91), (84), (33), (25), (13), (10), (7), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN650375
Quantity 100 µL
Price
392.86 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues in human Rb was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human Rb was used as an immunogen.
Alternative Name Rb
Background Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1, 2). Cell cycle-dependent phosphorylation by cdk's inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Synonyms: RB1, Retinoblastoma-associated protein, pp110,p105-Rb
Molecular Weight 110 kDA
Gene ID 5925
UniProt P06400
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-2000
Comment

Background: Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1, 2). Cell cycle-dependent phosphorylation by cdk's inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Rb Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Sherr: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, 1997 (PubMed).

Knudsen, Wang: "Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5771-83, 1997 (PubMed).

Lundberg, Weinberg: "Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes." in: Molecular and cellular biology, Vol. 18, Issue 2, pp. 753-61, 1998 (PubMed).

Hosts (287), (56), (2)
Reactivities (332), (218), (204), (109), (85), (70), (48), (1), (1), (1)
Applications (209), (100), (94), (91), (84), (33), (25), (13), (10), (7), (2), (1), (1)
Conjugates (10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Epitopes (32), (32), (29), (21), (20), (18), (17), (17), (16), (14), (10), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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