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Details for Product No. ABIN650376

Retinoblastoma 1 (RB1) (pSer780) antibody

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Antigen
Synonyms RB, pRb, OSRC, pp110, p105-Rb, Rb, Rb-1, P105-RB, PP110, RB11, zgc:154147, RB1
Epitope
»Alternatives pSer780
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN650376
Quantity 100 µL
Price
507.14 $   Plus shipping costs $45.00
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Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser780 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Serine 780.
Specificity A synthetic phospho-peptide corresponding to residues surrounding Ser780 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Serine 780.
Alternative Name Rb
Background Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdk',s inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Synonyms: RB1, Retinoblastoma-associated protein, pp110,p105-Rb
Molecular Weight 110 kDA
Gene ID 5925
UniProt P06400
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000 IP: ~~ 1:50 ICC: ~~ 1:250~1:500
Comment

Background: Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdk',s inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Rb Antibody Phospho (pS780) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Lee, Shew, Hong et al.: "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity." in: Nature, Vol. 329, Issue 6140, pp. 642-5, 1987 (PubMed).

Sherr: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, 1997 (PubMed).

Alternatives for antigen "Retinoblastoma 1 (RB1)", type "Antibodies"
Hosts (356), (106), (2)
Reactivities (446), (239), (223), (109), (87), (76), (48), (3), (2), (1), (1), (1), (1)
Applications (301), (134), (132), (101), (100), (73), (45), (19), (19), (16), (13), (2), (1)
Conjugates (13), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Epitopes (40), (36), (33), (24), (23), (21), (20), (20), (18), (18), (17), (7), (7), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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