anti-Retinoblastoma 1 antibody (RB1) (pThr373)

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Antigen
Alternatives
Epitope
pThr373
(48), (46), (45), (40), (32), (26), (25), (17), (17), (14), (13), (13), (9), (9), (7), (7), (6), (6), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(515), (254), (231), (7), (7), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Host
Rabbit
(450), (74), (3)
Clonality
Monoclonal
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
(22), (20), (20), (15), (13), (13), (10), (9), (9), (7), (7), (7), (7), (7), (7)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(331), (207), (138), (85), (83), (69), (41), (39), (33), (16), (10), (8), (8), (5), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 100 μL
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Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr373 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Threonine 373.
Specificity A synthetic phospho-peptide corresponding to residues surrounding Thr373 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Threonine 373.
Alternative Name Rb (RB1 Antibody Abstract)
Background Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdks inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Synonyms: RB1, Retinoblastoma-associated protein, pp110,p105-Rb
Molecular Weight 110 kDA
Gene ID 5925
UniProt P06400
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Pathways Cell Division Cycle
Application Notes IHC: = 1:250-500, WB: = 1:500-2000
Comment

Background: Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdks inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Rb Antibody Phospho (pT373) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Sherr: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, 1997 (PubMed).

Lee, Shew, Hong et al.: "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity." in: Nature, Vol. 329, Issue 6140, pp. 642-5, 1987 (PubMed).

Catalog No. ABIN650378
$481.43
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