Retinoblastoma Binding Protein 4 (RBBP4) antibody

Details for Product No. ABIN650384
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Antigen
Synonyms
RBBP-4, nurf55, rbap48, rbbp4, xrbbp4, 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Dmel\\CG4236, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, NURF55, Nurf, Nurf 55, Nurf ... show more
RBBP-4, nurf55, rbap48, rbbp4, xrbbp4, 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Dmel\\CG4236, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, NURF55, Nurf, Nurf 55, Nurf-55, Nurf55, P55, RbAp48, S(ls)3, caf-1, caf1, caf1 p55, d-CAF1, dCAF-1, dCAF-1 p55, dNURF, p55, p55 CAF1, p55/NURF-55, p55CAF1, RBBP4, rbb4-2, zgc:55349, zgc:77854, wu:fb33a09, wu:fb40e10, RBAP48, mRbAp48 show less
Reactivity
Human
(53), (23), (21), (12)
Host
Rabbit
(37), (17), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(45), (20), (15), (13), (10), (10), (8), (8), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN650384
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human RBBP4 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human RBBP4 was used as an immunogen.
Alternative Name RBBP4
Background RBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These complexes include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair as well as the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (1) The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins. Rb interacts with multiple cellular proteins that mediate its cellular function. p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein (2). Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb. RbAp48 (RBBP4) and RbAp46 are quantitatively the major Rb-associated proteins. Results suggest that RBBP4 and RbAp46 may have shared as well as unique functions in the regulation of cell proliferation and differentiation (3).
Synonyms: RBBP4, RBAP48, Histone-binding protein RBBP4, Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48
Molecular Weight 52 kDA
Gene ID 5928
UniProt Q09028
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:20000
Comment

Background: RBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These complexes include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair as well as the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (1) The growth suppression function of the retinoblastoma protein (Rb) is thought to be mediated by Rb binding to cellular proteins. Rb interacts with multiple cellular proteins that mediate its cellular function. p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein (2). Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb. RbAp48 (RBBP4) and RbAp46 are quantitatively the major Rb-associated proteins. Results suggest that RBBP4 and RbAp46 may have shared as well as unique functions in the regulation of cell proliferation and differentiation (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment RBBP4 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Qian, Lee: "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast." in: The Journal of biological chemistry, Vol. 270, Issue 43, pp. 25507-13, 1995 (PubMed).

Qian, Wang, Hollingsworth et al.: "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast." in: Nature, Vol. 364, Issue 6438, pp. 648-52, 1993 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Validation Images
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