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Ras Homolog Enriched in Brain (RHEB) antibody

Details for Product No. ABIN650388
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Antigen
Synonyms RHEB, rheb2, im:7161941, zgc:153231, RHEB2
Reactivity
Human
(72), (48), (48), (17), (17), (1), (1)
Host
Rabbit
(68), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(59), (23), (14), (13), (12), (5), (4), (3)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN650388
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human Rheb was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human Rheb was used as an immunogen.
Alternative Name Rheb
Background Rheb (Ras Homolog Enriched in brain) is a Ras-like small guanosine triphosphatase (GTPase) that is involved in cell growth and cell cycle progression. Rheb has also been suggested to have involvement in the TOR/S6K signaling pathway (1). It regulates the activity of the mammalian target of rapamycin, mTOR, a central regulator of cell growth, in response to growth factor stimulation and nutrient availability (2). It also interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, and is suggested to function in concert with H-Ras to dynamically integrate cAMP and growth factor signaling (3).
Synonyms: RHEB, RHEB2, GTP-binding protein Rheb, Ras homolog enriched in brain
Molecular Weight 21 kDA
Gene ID 6009
UniProt Q15382
Research Area Signaling, Protein Modifications, Cell Structure, Chromatin
Application Notes IHC: = 1:100-250, WB: = 1:5000-10000
Comment

Background: Rheb (Ras Homolog Enriched in brain) is a Ras-like small guanosine triphosphatase (GTPase) that is involved in cell growth and cell cycle progression. Rheb has also been suggested to have involvement in the TOR/S6K signaling pathway (1). It regulates the activity of the mammalian target of rapamycin, mTOR, a central regulator of cell growth, in response to growth factor stimulation and nutrient availability (2). It also interacts with and appears to regulate Raf-1 kinase, an essential component of the H-Ras signaling pathway, and is suggested to function in concert with H-Ras to dynamically integrate cAMP and growth factor signaling (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Rheb Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Tabancay, Gau, Machado et al.: "Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39921-30, 2003 (PubMed).

Hsu, Chern, Cai et al.: "Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase." in: Nature, Vol. 445, Issue 7129, pp. 785-8, 2007 (PubMed).

Bai, Ma, Liu et al.: "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38." in: Science (New York, N.Y.), Vol. 318, Issue 5852, pp. 977-80, 2007 (PubMed).

Validation Images
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