rho (RHO) (N-Term) antibody

Details for Product No. ABIN650390
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Antigen
Synonyms arha, arha2, xrhoa, arh12, rho12, rhoh12
Epitope
N-Term
(2), (1), (1)
Reactivity
Human, Rat (Rattus)
(15), (5), (4), (2)
Host
Rabbit
(16), (1)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(17), (3), (1), (1)
Pubmed 3 references available
Catalog no. ABIN650390
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues in the N-term of human Rho was used as immunogen. The antibody is predicted to detect RhoA, RhoB and RhoC based on sequence analysis.
Specificity A synthetic peptide corresponding to residues in the N-term of human Rho was used as immunogen. The antibody is predicted to detect RhoA, RhoB and RhoC based on sequence analysis.
Alternative Name Rho
Background Rho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families, the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on or off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extent cell transformation (5).
Synonyms: RHOA, ARH12, ARHA, RHO12, Transforming protein RhoA, H12
Molecular Weight 22 kDA
Gene ID 387
UniProt P61586
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer, Chromatin
Application Notes IHC: = 1:50-100, WB: = 1:500-2000
Comment

Background: Rho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families, the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on or off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extent cell transformation (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Rho Antibody (N-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Yeramian, Chardin, Madaule et al.: "Nucleotide sequence of human rho cDNA clone 12." in: Nucleic acids research, Vol. 15, Issue 4, pp. 1869, 1987 (PubMed).

Khosravi-Far, Solski, Clark et al.: "Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation." in: Molecular and cellular biology, Vol. 15, Issue 11, pp. 6443-53, 1995 (PubMed).

Boguski, McCormick: "Proteins regulating Ras and its relatives." in: Nature, Vol. 366, Issue 6456, pp. 643-54, 1994 (PubMed).

Hosts (16), (1)
Reactivities (15), (5), (4), (2)
Applications (17), (3), (1), (1)
Epitopes (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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