Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (N-Term) antibody

Details for Product No. ABIN650398
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Antigen
Synonyms CD136, CDw136, PTK8, RON, Fv-2, Fv2, Ron, STK, Cdw136, Ptk8, Stk
Epitope
N-Term
(34), (19), (18), (17), (17), (11), (8), (6), (6), (6), (5), (5), (2), (1), (1), (1), (1)
Reactivity
Human
(160), (100), (65), (11), (11)
Host
Rabbit
(166), (20), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(82), (67), (57), (34), (30), (12), (8), (5), (4), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN650398
450.00 $
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Immunogen A synthetic peptide corresponding to residues near the N-terminus of human Ron was used as an immunogen.
Clone EP1132Y
Specificity A synthetic peptide corresponding to residues near the N-terminus of human Ron was used as an immunogen.
Alternative Name Ron
Background Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell dissociation, motility, and matrix invasion (1). Ron, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. It has been shown that the Ron gene is expressed in several epithelial tissues as well as in granulocytes and monocytes. The major RON transcript is translated into a glycosylated single chain precursor, cleaved into a 185 kDa heterodimer (p185Ron) of 35 (alpha) and 150 kDa (beta) disulfide-linked chains, before exposure at the cell surface (2).
Synonyms: MST1R, PTK8, RON, Macrophage-stimulating protein receptor beta chain, p185-Ron,CDw136
Molecular Weight 35/180 kDA
Gene ID 4486
UniProt Q04912
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes IHC: = 1:100-250, WB: = 1:200000
Comment

Background: Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell dissociation, motility, and matrix invasion (1). Ron, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. It has been shown that the Ron gene is expressed in several epithelial tissues as well as in granulocytes and monocytes. The major RON transcript is translated into a glycosylated single chain precursor, cleaved into a 185 kDa heterodimer (p185Ron) of 35 (alpha) and 150 kDa (beta) disulfide-linked chains, before exposure at the cell surface (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Ron Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Gaudino, Follenzi, Naldini et al.: "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP." in: The EMBO journal, Vol. 13, Issue 15, pp. 3524-32, 1994 (PubMed).

Ghigna, Giordano, Shen et al.: "Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene." in: Molecular cell, Vol. 20, Issue 6, pp. 881-90, 2005 (PubMed).

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