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Details for Product No. ABIN650398

Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) antibody

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Antigen
Synonyms RON, PTK8, CD136, CDw136, Fv2, Ron, STK, Fv-2, Stk, Ptk8, Cdw136
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN650398
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen A synthetic peptide corresponding to residues near the N-terminus of human Ron was used as an immunogen.
Clone EP1132Y
Specificity A synthetic peptide corresponding to residues near the N-terminus of human Ron was used as an immunogen.
Alternative Name Ron
Background Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell dissociation, motility, and matrix invasion (1). Ron, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. It has been shown that the Ron gene is expressed in several epithelial tissues as well as in granulocytes and monocytes. The major RON transcript is translated into a glycosylated single chain precursor, cleaved into a 185 kDa heterodimer (p185Ron) of 35 (alpha) and 150 kDa (beta) disulfide-linked chains, before exposure at the cell surface (2).
Synonyms: MST1R, PTK8, RON, Macrophage-stimulating protein receptor beta chain, p185-Ron,CDw136
Molecular Weight 35/180 kDA
Gene ID 4486
UniProt Q04912
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes The suggested dilution is: WB: ~~ 1:200000 IP: ~~ 1:30 FC: ~~ 1:40 ICC: ~~ 1:50~100 IHC: ~~ 1:100~250
Comment

Background: Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell dissociation, motility, and matrix invasion (1). Ron, a cDNA homologous to the hepatocyte growth factor (HGF) receptor gene (MET), encodes a putative tyrosine kinase. It has been shown that the Ron gene is expressed in several epithelial tissues as well as in granulocytes and monocytes. The major RON transcript is translated into a glycosylated single chain precursor, cleaved into a 185 kDa heterodimer (p185Ron) of 35 (alpha) and 150 kDa (beta) disulfide-linked chains, before exposure at the cell surface (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Ron Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Gaudino, Follenzi, Naldini et al.: "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP." in: The EMBO journal, Vol. 13, Issue 15, pp. 3524-32, 1994 (PubMed).

Ghigna, Giordano, Shen et al.: "Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene." in: Molecular cell, Vol. 20, Issue 6, pp. 881-90, 2005 (PubMed).

Alternatives for antigen "Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R)", type "Antibodies"
Hosts (135), (14), (2)
Reactivities (124), (92), (64), (11), (11)
Applications (55), (50), (49), (45), (35), (8), (6), (5), (5), (2), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (1)
Epitopes (34), (17), (17), (11), (11), (7), (6), (6), (5), (2), (2), (2), (2), (1)
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