SATB Homeobox 1 (SATB1) (N-Term) antibody

Details for Product No. ABIN650419
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms SATB1, 2610306G12Rik, AW413156
Epitope
N-Term
(16), (12), (10), (7), (6), (1), (1), (1), (1)
Reactivity
Human
(85), (38), (26), (14), (13), (13), (12)
Host
Rabbit
(52), (28), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(74), (32), (27), (25), (22), (11), (10), (8), (4), (4), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 100 μL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN650419
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide corresponding to residues near the N-terminus in human SATB1 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues near the N-terminus in human SATB1 was used as an immunogen.
Alternative Name SATB1
Background Special AT-rich sequence-binding protein 1 (SATB1) is a global chromatin organizer and nuclear transcription factor which integrates higher-order chromatin architecture with gene regulation (1). SATB1 specifically binds to nuclear matrix/scaffold-associating DNAs (MARs/SARs), which is made of AT-rich DNA sequences with one strand consisting of ATC sequences. Studies have shown that in cooperation with promyelocytic leukemia protein (PML), SATB1 and PML function as a regulatory complex which controls transcription through restructuring dynamic chromatin-loop architecture. SATB1 interacts with PML to organize the MHC class-I locus into distinct higher-order chromatin loops by anchoring MARs to nuclear matrix at fixed distances (2). As a key player in the immune system, SATB1 has been linked to regulating gene expression during the differentiation and activation of T cells. In cancer, SATB1 has been shown to reprogram chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis (3).
Molecular Weight 100 kDA
Gene ID 8578
UniProt Q01826
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:1000-10000
Comment

Background: Special AT-rich sequence-binding protein 1 (SATB1) is a global chromatin organizer and nuclear transcription factor which integrates higher-order chromatin architecture with gene regulation (1). SATB1 specifically binds to nuclear matrix/scaffold-associating DNAs (MARs/SARs), which is made of AT-rich DNA sequences with one strand consisting of ATC sequences. Studies have shown that in cooperation with promyelocytic leukemia protein (PML), SATB1 and PML function as a regulatory complex which controls transcription through restructuring dynamic chromatin-loop architecture. SATB1 interacts with PML to organize the MHC class-I locus into distinct higher-order chromatin loops by anchoring MARs to nuclear matrix at fixed distances (2). As a key player in the immune system, SATB1 has been linked to regulating gene expression during the differentiation and activation of T cells. In cancer, SATB1 has been shown to reprogram chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment SATB1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Kumar, Bischof, Purbey et al.: "Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus." in: Nature cell biology, Vol. 9, Issue 1, pp. 45-56, 2007 (PubMed).

Galande, Purbey, Notani et al.: "The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1." in: Current opinion in genetics & development, Vol. 17, Issue 5, pp. 408-14, 2007 (PubMed).

Han, Russo, Kohwi et al.: "SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis." in: Nature, Vol. 452, Issue 7184, pp. 187-93, 2008 (PubMed).

Validation Images
Did you look for something else?
back to top