Acetyl LDL Receptor (SCARF1) antibody

Antigen: Acetyl LDL Receptor (SCARF1)

Synonyms: SREC, KIAA0149, MGC47738

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN650421

Additional Information

Alternative name: SCARF1

Gene ID: 9531

UniProt: Q14162

Immunogen: A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.

Molecular Weight: 90 kDA

Comments:

Background: Scavenger receptor class F member 1 (SCARF1) mediates the selective uptake of modified low density lipoprotein (LDL), such as acetylated LDL and oxidized LDL, into endothelial cells (1). It also mediates heterophilic interactions, suggesting that it functions as an adhesion protein (2). SCARF1 has several characteristic domain structures, an N-terminal extracellular domain with seven epidermal growth factor (EGF)-like cysteine pattern signatures, and an unusually long C-terminal cytoplasmic domain composed of a Ser/Pro-rich region followed by a Gly-rich region. SCARF1 is expressed at high levels in endothelial cells but not in smooth muscle cells (1).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:10~100 ICC: ~~ 1:100~250 IHC: ~~ 1:250~500

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: SCARF1 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Adachi, Tsujimoto: "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2." in: The Journal of biological chemistry, Vol. 277, Issue 27, pp. 24014-21, 2002 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).