Acetyl LDL Receptor (SCARF1) antibody

Details for Product No. ABIN650421
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Antigen
Synonyms SREC, SREC-I, SREC1, AA986099, mKIAA0149
Reactivity
Human
(12), (3), (3)
Host
Rabbit
(6), (5), (1)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(11), (8), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN650421
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.
Alternative Name SCARF1
Background Scavenger receptor class F member 1 (SCARF1) mediates the selective uptake of modified low density lipoprotein (LDL), such as acetylated LDL and oxidized LDL, into endothelial cells (1). It also mediates heterophilic interactions, suggesting that it functions as an adhesion protein (2). SCARF1 has several characteristic domain structures, an N-terminal extracellular domain with seven epidermal growth factor (EGF)-like cysteine pattern signatures, and an unusually long C-terminal cytoplasmic domain composed of a Ser/Pro-rich region followed by a Gly-rich region. SCARF1 is expressed at high levels in endothelial cells but not in smooth muscle cells (1).
Molecular Weight 90 kDA
Gene ID 9531
UniProt Q14162
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:250-500, WB: = 1:1000-10000
Comment

Background: Scavenger receptor class F member 1 (SCARF1) mediates the selective uptake of modified low density lipoprotein (LDL), such as acetylated LDL and oxidized LDL, into endothelial cells (1). It also mediates heterophilic interactions, suggesting that it functions as an adhesion protein (2). SCARF1 has several characteristic domain structures, an N-terminal extracellular domain with seven epidermal growth factor (EGF)-like cysteine pattern signatures, and an unusually long C-terminal cytoplasmic domain composed of a Ser/Pro-rich region followed by a Gly-rich region. SCARF1 is expressed at high levels in endothelial cells but not in smooth muscle cells (1).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment SCARF1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Adachi, Tsujimoto: "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2." in: The Journal of biological chemistry, Vol. 277, Issue 27, pp. 24014-21, 2002 (PubMed).

"The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

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