Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) (C-Term) antibody

Details for Product No. ABIN650430
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Antigen
Epitope
C-Term
(21), (14), (13), (10), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(102), (68), (55)
Host
Rabbit
(84), (21)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(68), (37), (20), (16), (10), (5), (4), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Immunogen A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Specificity A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Alternative Name SHIP (INPP5D Antibody Abstract)
Background SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).
Synonyms: INPP5D, SHIP, SHIP1, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, p150Ship
Molecular Weight 145 kDA
Gene ID 3635
UniProt O00145
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Metabolism
Application Notes IHC: = 1:100-250, WB: = 1:1000-10000
Comment

Background: SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment SHIP Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Malbec, Schmitt, Bruhns et al.: "Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB." in: The Journal of biological chemistry, Vol. 276, Issue 32, pp. 30381-91, 2001 (PubMed).

Tridandapani, Kelley, Pradhan et al.: "Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif." in: Molecular and cellular biology, Vol. 17, Issue 8, pp. 4305-11, 1997 (PubMed).

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Catalog No. ABIN650430
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