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Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) antibody

Antigen

Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D)
Synonyms SHIP, SHIP1, hp51CN, SIP-145, MGC104855, MGC142140, MGC142142, INPP5D, MGC157261, inpp5d, ship, ship1, MGC68993
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN650430
Quantity 100ul
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name SHIP
Gene ID 3635
UniProt O00145
Immunogen A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Description Other names: INPP5D, SHIP, SHIP1, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, p150Ship
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Molecular Weight 145 kDA
Comments

Background: SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:1000~10000 IP: ~~ 1:50 FC: ~~ 1:20 IHC: ~~ 1:100~250
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage SHIP Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Metabolism
Restrictions For Research Use only

Publications
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Product Tridandapani, Kelley, Pradhan et al.: "Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif." in: Molecular and cellular biology, Vol. 17, Issue 8, pp. 4305-11, 1997 (PubMed).

Malbec, Schmitt, Bruhns et al.: "Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB." in: The Journal of biological chemistry, Vol. 276, Issue 32, pp. 30381-91, 2001 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D)", type "Antibodies"
Hosts Rabbit (70), Mouse (8)
Reactivities Human (77), Mouse (Murine) (53), Rat (Rattus) (53), Cow (Bovine) (38), Dog (Canine) (19), Horse (Equine) (19), Pig (Porcine) (19), Cat (Feline) (1), Chicken (1)
Applications Western Blotting (WB) (40), Immunofluorescence (IF) (32), ELISA (29), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (13), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunoprecipitation (IP) (5), Flow Cytometry (FACS) (4), Immunohistochemistry (IHC) (3), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Immunocytochemistry (ICC) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), Alexa Flour 488 (1)
Epitopes pTyr1020 (19), C-Term (9), N-Term (8), pTyr1021,C-Term (3), Center (2), AA 7-133 (1), Internal Region (1), pTyr1021 (1)