SMAD Family Member 4 (SMAD4) (C-Term) antibody

Details for Product No. ABIN650453
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Antigen
Synonyms DPC4, JIP, MADH4, MYHRS, XSmad4alpha, Xsmad4, dpc4, jip, madh4, smad4, xsmad4a, AW743858, D18Wsu70e, Madh4
Epitope
C-Term
(10), (8), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(98), (47), (42), (3), (3), (2), (1)
Host
Rabbit
(58), (37), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(80), (51), (18), (14), (10), (10), (10), (7), (6), (6), (2), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN650453
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to residues in the C-term of human Smad 4 was used as immunogen.
Specificity A synthetic peptide corresponding to residues in the C-term of human Smad 4 was used as immunogen.
Alternative Name Smad4
Background Smad 4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided in 3 subgroups based on their structure and functions, pathway-restricted, common mediator and inhibitory Smad. Smad 4 is the common Smad (co-Smad) (1-2). Previously identified as the tumor suppressor DPC4 (deleted in pancreatic carcinoma, locus 4), Smad 4 is functionally distinct among the Smad family, and is required for the assembly and transcriptional activation of diverse, Smad-DNA complexes (3). In contrast to the R-Smads, Smad 4 is not regulated by phosphorylation, but acts as a common mediator of TGF-Beta, activin, and bone morphogenetic protein signaling responses (4). Smad 4 is frequently inactivated in pancreatic, biliary and colorectal tumors (5-6).
Synonyms: SMAD4, DPC4, MADH4, Mothers against decapentaplegic homolog 4, SMAD 4,hSMAD4,Deletion target in pancreatic carcinoma 4
Molecular Weight 65 kDA
Gene ID 4089
UniProt Q13485
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes The suggested dilution is: WB: = 1:250-500 , IHC: = 1:100-250
Comment

Background: Smad 4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided in 3 subgroups based on their structure and functions, pathway-restricted, common mediator and inhibitory Smad. Smad 4 is the common Smad (co-Smad) (1-2). Previously identified as the tumor suppressor DPC4 (deleted in pancreatic carcinoma, locus 4), Smad 4 is functionally distinct among the Smad family, and is required for the assembly and transcriptional activation of diverse, Smad-DNA complexes (3). In contrast to the R-Smads, Smad 4 is not regulated by phosphorylation, but acts as a common mediator of TGF-β,, activin, and bone morphogenetic protein signaling responses (4). Smad 4 is frequently inactivated in pancreatic, biliary and colorectal tumors (5-6).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment Smad4 Antibody (C-term) can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Eppert, Scherer, Ozcelik et al.: "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma." in: Cell, Vol. 86, Issue 4, pp. 543-52, 1996 (PubMed).

Goggins, Shekher, Turnacioglu et al.: "Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas." in: Cancer research, Vol. 58, Issue 23, pp. 5329-32, 1998 (PubMed).

Hosts (58), (37), (7)
Reactivities (98), (47), (42), (3), (3), (2), (1)
Applications (80), (51), (18), (14), (10), (10), (10), (7), (6), (6), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (8), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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