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SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) antibody

Details for Product No. ABIN650461
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Antigen
Synonyms SMURF2, 2810411E22Rik, AI558114, AI649275, RGD1310067, wu:fb82a11, wu:fc41c02
Reactivity
Human, Rat (Rattus)
(41), (18), (12), (12), (12)
Host
Rabbit
(39), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (16), (14), (10), (10), (8), (2)
Pubmed 1 reference available
Quantity 100 µL
Options
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Catalog No. ABIN650461
392.86 $
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Immunogen A synthetic peptide corresponding to residues in human Smurf2 was used as immunogen.
Specificity A synthetic peptide corresponding to residues in human Smurf2 was used as immunogen.
Alternative Name Smurf2
Background Smad ubiquitination regulatory factor proteins (Smurf1 and Smurf2) are E3 ubiquitin ligase that belongs to the Hect family. Smurf proteins play an important role as regulators in TGF-beta pathway by ubiquitinating Smads and Smads associated proteins for proteasome degradation (1). Specifically, Smurf1 interacts with Smad1 and Smad5 for degradation, while Smurf2 ubiquitinates Smad1 and Smad2. Smads also functions to recruit Smurfs to various pathway components such as TGF-beta and SnoN. In particular, Smad7 acts as an adaptor protein between Smurfs and TGF-Beta receptors, allowing the receptors to be marked by Smurfs for degradation (2). Smurf2 interacts with all members of Smad family except for Smad4 and it is expressed various tissues and cell lines, such as placenta and ovarian cancer cell lines. Smurf2 has been implicated in the tumor formation and diseases progression (3).
Synonyms: SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2
Molecular Weight 86 kDA
Gene ID 64750
UniProt Q9HAU4
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-1:10000
Comment

Background: Smad ubiquitination regulatory factor proteins (Smurf1 and Smurf2) are E3 ubiquitin ligase that belongs to the Hect family. Smurf proteins play an important role as regulators in TGF-beta pathway by ubiquitinating Smads and Smads associated proteins for proteasome degradation (1). Specifically, Smurf1 interacts with Smad1 and Smad5 for degradation, while Smurf2 ubiquitinates Smad1 and Smad2. Smads also functions to recruit Smurfs to various pathway components such as TGF-beta and SnoN. In particular, Smad7 acts as an adaptor protein between Smurfs and TGF-Beta receptors, allowing the receptors to be marked by Smurfs for degradation (2). Smurf2 interacts with all members of Smad family except for Smad4 and it is expressed various tissues and cell lines, such as placenta and ovarian cancer cell lines. Smurf2 has been implicated in the tumor formation and diseases progression (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Smurf2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Hershko, Ciechanover: "The ubiquitin system." in: Annual review of biochemistry, Vol. 67, pp. 425-79, 1998 (PubMed).

Validation Images
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