SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Details for Product No. ABIN650468
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Antigen
Synonyms Qscn6, Qsox, Sox-2, rSOx, ANOP3, MCOPS3, RGD1565646, SRY-box2, Xsox-2, anop3, mcops3, sox-2, lcc, ysb, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Reactivity
Human
(196), (66), (45), (21), (20), (20), (16), (12), (5), (4), (4), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(159), (43), (5)
Clonality
Monoclonal
Conjugate
Un-conjugated
(11), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(144), (74), (39), (33), (31), (29), (26), (24), (10), (10), (8), (3), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN650468
450.00 $
Plus shipping costs $45.00

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Immunogen A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Alternative Name SOX2
Background SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2).
Molecular Weight 35 kDA
Gene ID 6657
UniProt P48431
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:10000-50000 , IHC: = 1:100-250
Comment

Background: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment SOX2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Parry, Martorano, Cotton: "Management of life-threatening asthma with intravenous isoproterenol infusions." in: American journal of diseases of children (1960), Vol. 130, Issue 1, pp. 39-42, 1976 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Masui, Nakatake, Toyooka et al.: "Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells." in: Nature cell biology, Vol. 9, Issue 6, pp. 625-35, 2007 (PubMed).

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