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SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Clonality Monoclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN650469
Quantity 100ul  (Variants)
Price 450.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name SOX2
Gene ID 5174
UniProt P48431
Immunogen A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Characteristics Rabbit Monoclonal Antibody
Specificity A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.
Molecular Weight 35 kDA
Comments

Background: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2).

Application Details
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Application Notes The suggested dilution is: WB: ~~ 1:500~1000 IP: ~~ 1:10 IHC: ~~ 1:50~100
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage SOX2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Parry, Martorano, Cotton: "Management of life-threatening asthma with intravenous isoproterenol infusions." in: American journal of diseases of children (1960), Vol. 130, Issue 1, pp. 39-42, 1976 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Masui, Nakatake, Toyooka et al.: "Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells." in: Nature cell biology, Vol. 9, Issue 6, pp. 625-35, 2007 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (86), Mouse (19), Goat (4)
Reactivities Human (103), Mouse (Murine) (35), Rat (Rattus) (30), Dog (Canine) (23), Cow (Bovine) (22), Pig (Porcine) (22), Chicken (21), Sheep (Ovine) (20), Guinea Pig (18), Zebrafish (2), Chimpanzee (1), Xenopus laevis (1)
Applications Western Blotting (WB) (74), ELISA (57), Immunofluorescence (IF) (31), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (13), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (16), C-Term (4), AA 1-170 (2), AA 50-100 (2), Ala30 (2), Center (2), Cys265 (2), Internal Region (2), AA 100-150 (1), AA 76-80 (1), C-Term, AA 240-260 (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)