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Microtubule-Associated Protein tau (MAPT) (pSer622) antibody

Details for Product No. ABIN650513
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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Epitope
pSer622
(44), (33), (33), (30), (30), (30), (30), (26), (26), (25), (25), (25), (24), (23), (18), (13), (12), (11), (11), (11), (11), (10), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(858), (452), (424), (43), (8), (6), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(797), (87), (10), (8), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(9), (4), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(791), (343), (239), (91), (75), (60), (31), (30), (16), (13), (13), (13), (9), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN650513
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Immunogen A synthetic phospho-peptide corresponding to residues surrounding serine 622 of human Tau was used as immunogen. This antibody detects Tau phospholyated and unphospholyated on serine 622.
Specificity A synthetic phospho-peptide corresponding to residues surrounding serine 622 of human Tau was used as immunogen. This antibody detects Tau phospholyated and unphospholyated on serine 622.
Alternative Name Tau
Background Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Synonyms: MAPT, MAPTL, MTBT1, TAU, Microtubule-associated protein tau, Neurofibrillary tangle protein,Paired helical filament-tau
Molecular Weight 50 - 70 kDA
Gene ID 4137
UniProt P10636
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Neurology
Application Notes The suggested dilution is: WB: = 1:2000
Comment

Background: Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Tau Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Jakes, Novak, Davison et al.: "Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease." in: The EMBO journal, Vol. 10, Issue 10, pp. 2725-9, 1991 (PubMed).

Goedert, Wischik, Crowther et al.: "Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 11, pp. 4051-5, 1988 (PubMed).

Maas, Eidenmüller, Brandt: "Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments." in: The Journal of biological chemistry, Vol. 275, Issue 21, pp. 15733-40, 2000 (PubMed).

Validation Images
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