Ras Homolog Gene Family, Member Q (RHOQ) antibody

Details for Product No. ABIN650521
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Antigen
Synonyms zgc:55997, wu:fi15a09, CHTC10, ARHQ, RASL7A, TC10, TC10A, Tc10, Arhq
Reactivity
Human
(14), (3), (2)
Host
Rabbit
(11), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(13), (10), (6), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µL
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Catalog No. ABIN650521
450.00 $
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Immunogen A synthetic peptide corresponding to the third GTP unit of human TC10 was used as immunogen.
Specificity A synthetic peptide corresponding to the third GTP unit of human TC10 was used as immunogen.
Alternative Name TC10
Background TC10 is a member of the Rho family of GTP-binding proteins and is closely related to Cdc42 and Rac 1. Cycling between inactive and active GTP-bound state, active TC10 can directly interact with Cdc42 kinase, p21-activated protein kinases as well as other kinases (1). Constitutive expression of active TC10 mutants (TC10/Q75L) in fibroblast decrease actin stress fiber and formation of plasma membrane microspikes, while wild type TC10 has no effect on fibroblast cell morphology (2). Mostly expressed in adipose and muscle tissues, TC10 has been found to be activated by C3G (from the insulin pathway) in adipocytes (3).
Synonyms: RHOQ, ARHQ, RASL7A, TC10, Rho-related GTP-binding protein RhoQ, Ras-related GTP-binding protein TC10,Ras-like protein family member 7A
Molecular Weight 25 kDA
Gene ID 23433
UniProt P17081
Research Area Signaling, Protein Modifications, Cell Structure, Chromatin
Application Notes WB: = 1:1000-10000
Comment

Background: TC10 is a member of the Rho family of GTP-binding proteins and is closely related to Cdc42 and Rac 1. Cycling between inactive and active GTP-bound state, active TC10 can directly interact with Cdc42 kinase, p21-activated protein kinases as well as other kinases (1). Constitutive expression of active TC10 mutants (TC10/Q75L) in fibroblast decrease actin stress fiber and formation of plasma membrane microspikes, while wild type TC10 has no effect on fibroblast cell morphology (2). Mostly expressed in adipose and muscle tissues, TC10 has been found to be activated by C3G (from the insulin pathway) in adipocytes (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TC10 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Murphy, Solski, Jillian et al.: "Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth." in: Oncogene, Vol. 18, Issue 26, pp. 3831-45, 1999 (PubMed).

Baumann, Ribon, Kanzaki et al.: "CAP defines a second signalling pathway required for insulin-stimulated glucose transport." in: Nature, Vol. 407, Issue 6801, pp. 202-7, 2000 (PubMed).

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