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Details for Product No. ABIN650522

Transcription Factor 3 (TCF3) antibody

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Antigen
Synonyms Pan2, Tcfe2a
Reactivity
Human
Host
Rabbit
Clonality Monoclonal
Application
Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN650522
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.
Alternative Name TCF-3
Background T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2).
Synonyms: TCF7L1, TCF3, Transcription factor 7-like 1, HMG box transcription factor 3
Molecular Weight 68 kDA
Gene ID 83439
UniProt Q9HCS4
Research Area Translation Factors, Cell Signaling, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:1000~5000 FC: ~~ 1:100
Comment

Background: T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment TCF-3 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications "The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Tam, Lim, Han et al.: "T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 8, pp. 2019-31, 2008 (PubMed).

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