Transcription Factor 4 (TCF4) (N-Term) antibody

Details for Product No. ABIN650523
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Antigen
Synonyms
TCF7L2, TCF4, XE2, Xtcf-4, Xtcf4, e2-A, tcf-4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4, bHLHb19, 5730422P05Rik, ASP-I2, E2.2, ITF-2b, ME2, MITF-2A, MITF-2B, TFE, Tcf-4, T ... show more
TCF7L2, TCF4, XE2, Xtcf-4, Xtcf4, e2-A, tcf-4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4, bHLHb19, 5730422P05Rik, ASP-I2, E2.2, ITF-2b, ME2, MITF-2A, MITF-2B, TFE, Tcf-4, TCF4B, TCF4E, Tcf4, mTcf-4B, mTcf-4E, GE2 show less
Epitope
N-Term
(14), (7), (4), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(40), (11), (8), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(26), (13), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(39), (15), (11), (10), (7), (7), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN650523
450.00 $
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Immunogen A synthetic peptide corresponding to residues near the N-terminus of human TCF-4 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues near the N-terminus of human TCF-4 was used as an immunogen.
Alternative Name TCF-4
Background TCF4 (HMG box transcription factor 4) is a member of the lymphoid enhancer factor family of transcription factors. Essential during development, along with beta catenin and Bcl 9, TCF4 participates in the Wnt signaling thru transactivation of downstreams genes (1). Commonly found in intestinal epithelium, TCF4 is required in the maintenance of crypt stem cell compartments of small intestines (2). Mutation in TCF4 has implicated in colorectal cancer and high expression of TCF4 variants has been linked in increased risk of type II diabetes (3).
Synonyms: TCF7L2, TCF4, Transcription factor 7-like 2, HMG box transcription factor 4,T-cell-specific transcription factor 4
Molecular Weight 66/72 kDA
Gene ID 6934
UniProt Q9NQB0
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: TCF4 (HMG box transcription factor 4) is a member of the lymphoid enhancer factor family of transcription factors. Essential during development, along with beta catenin and Bcl 9, TCF4 participates in the Wnt signaling thru transactivation of downstreams genes (1). Commonly found in intestinal epithelium, TCF4 is required in the maintenance of crypt stem cell compartments of small intestines (2). Mutation in TCF4 has implicated in colorectal cancer and high expression of TCF4 variants has been linked in increased risk of type II diabetes (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TCF-4 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Grant, Thorleifsson, Reynisdottir et al.: "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes." in: Nature genetics, Vol. 38, Issue 3, pp. 320-3, 2006 (PubMed).

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