Transcription Factor 4 (TCF4) antibody

Antigen: Transcription Factor 4 (TCF4)

Synonyms: E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724, ME2, TFE, E2.2, ITF-2, SEF-2, Tcf-4, ASP-I2, ITF-2b, MITF-2A, MITF-2B, 5730422P05Rik, TCF4, TCF7L2, MGC128514, MGC155227

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Certificates: ISO 9001:2008

Catalog no.: ABIN650523

Additional Information

Alternative name: TCF-4

Gene ID: 6934

UniProt: Q9NQB0

Immunogen: A synthetic peptide corresponding to residues near the N-terminus of human TCF-4 was used as an immunogen.

Description: Other names: TCF7L2, TCF4, Transcription factor 7-like 2, HMG box transcription factor 4,T-cell-specific transcription factor 4

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues near the N-terminus of human TCF-4 was used as an immunogen.

Molecular Weight: 66/72 kDA

Comments:

Background: TCF4 (HMG box transcription factor 4) is a member of the lymphoid enhancer factor family of transcription factors. Essential during development, along with beta catenin and Bcl 9, TCF4 participates in the Wnt signaling thru transactivation of downstreams genes (1). Commonly found in intestinal epithelium, TCF4 is required in the maintenance of crypt stem cell compartments of small intestines (2). Mutation in TCF4 has implicated in colorectal cancer and high expression of TCF4 variants has been linked in increased risk of type II diabetes (3).

Synonyms: E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724, ME2, TFE, E2.2, ITF-2, SEF-2, Tcf-4, ASP-I2, ITF-2b, MITF-2A, MITF-2B, 5730422P05Rik, TCF4, TCF7L2, MGC128514, MGC155227

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~5000 IP: ~~ 1:50 FC: ~~ 1:50 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: TCF-4 Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Grant, Thorleifsson, Reynisdottir et al.: "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes." in: Nature genetics, Vol. 38, Issue 3, pp. 320-3, 2006 (PubMed).