Deoxynucleotidyltransferase, terminal (DNTT) antibody

Details for Product No. ABIN650526
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Antigen
Synonyms TDT, Tdt, BB160593, dntt-A, TdT
Reactivity
Human
(87), (25), (24), (14), (5), (3), (1), (1)
Host
Rabbit
(73), (26)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (29), (13), (10), (8), (6), (5), (4), (3), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN650526
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to residues on the C terminus of human TDT was used as an immunogen.
Specificity A synthetic peptide corresponding to residues on the C terminus of human TDT was used as an immunogen.
Alternative Name TDT
Background Terminal deoxynucleotidyl transferase (TDT) is a unique DNA polymerase that changes the addition of deoxynucleoside 5メ-triphosphate to the 3メ-end of a DNA initiator without template direction (1). TDT contributes to the generation of junctional diversity in antigen receptors of immature lymphocytes, and its expression serves as a developmental marker for the sites of teleost lymphopoiesis (2). TDT is also an oligoclonal marker characterizing several populations of undifferentiated or poorly differentiated blasts that tend to develop towards or along the lymphoid pathway. Together with specific immunological markers, this enzyme is useful to define the particular type of leukemic cells (3).
Synonyms: DNTT, TDT, DNA nucleotidylexotransferase, Terminal addition enzyme,Terminal deoxynucleotidyltransferase
Molecular Weight 58 kDA
Gene ID 1791
UniProt P04053
Research Area Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: = 1:1000-5000
Comment

Background: Terminal deoxynucleotidyl transferase (TDT) is a unique DNA polymerase that changes the addition of deoxynucleoside 5メ-triphosphate to the 3メ-end of a DNA initiator without template direction (1). TDT contributes to the generation of junctional diversity in antigen receptors of immature lymphocytes, and its expression serves as a developmental marker for the sites of teleost lymphopoiesis (2). TDT is also an oligoclonal marker characterizing several populations of undifferentiated or poorly differentiated blasts that tend to develop towards or along the lymphoid pathway. Together with specific immunological markers, this enzyme is useful to define the particular type of leukemic cells (3).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment TDT Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications "The universal protein resource (UniProt)." in: Nucleic acids research, Vol. 36, Issue Database issue, pp. D190-5, 2008 (PubMed).

Hosts (73), (26)
Reactivities (87), (25), (24), (14), (5), (3), (1), (1)
Applications (49), (29), (13), (10), (8), (6), (5), (4), (3), (2), (1)
Conjugates (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (10), (4), (2), (1), (1), (1), (1), (1)
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