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Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3) (PH domain) antibody

Details for Product No. ABIN650528
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Antigen
Synonyms NR4A3, Nr4a3, CHN, CSMF, MINOR, NOR1, TEC, AI573420, NOR-1, Nor1, NOR-2, MmTRA1a, MmTRA1b, Tra1, Tra1a, Tra1b, Tras1, Tras2, PSCTK4
Epitope
PH domain
(20), (14), (9), (8), (8), (8), (7), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(112), (54), (38), (13), (1), (1), (1), (1)
Host
Rabbit
(101), (26)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (7), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(98), (56), (20), (20), (9), (9), (8), (3), (2)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN650528
450.00 $
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Immunogen A synthetic peptide corresponding to residues in the PH domain of human Tec was used as immunogen.
Specificity A synthetic peptide corresponding to residues in the PH domain of human Tec was used as immunogen.
Alternative Name TEC
Background Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).
Synonyms: TEC, PSCTK4, Tyrosine-protein kinase Tec
Molecular Weight 66 kDA
Gene ID 7006
UniProt P42680
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes IHC: = 1:50-100, WB: = 1:5000-10000
Comment

Background: Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TEC Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Vihinen, Nilsson, Smith: "Tec homology (TH) adjacent to the PH domain." in: FEBS letters, Vol. 350, Issue 2-3, pp. 263-5, 1994 (PubMed).

Validation Images
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