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Details for Product No. ABIN650528

Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3) antibody

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Antigen
Synonyms CHN, TEC, CSMF, NOR1, MINOR, Nor1, NOR-1, AI573420, NOR-2, Nr4a3, NR4A3
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN650528
Quantity 100 µL
Price
450.00 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide corresponding to residues in the PH domain of human Tec was used as immunogen.
Specificity A synthetic peptide corresponding to residues in the PH domain of human Tec was used as immunogen.
Alternative Name TEC
Background Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).
Synonyms: TEC, PSCTK4, Tyrosine-protein kinase Tec
Molecular Weight 66 kDA
Gene ID 7006
UniProt P42680
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: ~~ 1:5000~10000 IP: ~~ 1:50 FC: ~~ 1:30 ICC: ~~ 1:100~250 IHC: ~~ 1:50~100
Comment

Background: Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Storage -20 °C
Storage Comment TEC Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Vihinen, Nilsson, Smith: "Tec homology (TH) adjacent to the PH domain." in: FEBS letters, Vol. 350, Issue 2-3, pp. 263-5, 1994 (PubMed).

Alternatives for antigen "Nuclear Receptor Subfamily 4, Group A, Member 3 (NR4A3)", type "Antibodies"
Hosts (61), (18)
Reactivities (73), (29), (21), (1), (1), (1), (1), (1)
Applications (58), (30), (18), (10), (8), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (8), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1)
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