Transmembrane Protease, serine 2 (TMPRSS2) antibody

Details for Product No. ABIN650540
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Antigen
Synonyms PP9284, PRSS10, D16Ertd61e
Reactivity
Human, Rat (Rattus)
(30), (18), (18), (17), (17)
Host
Rabbit
(26), (5), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(16), (14), (8), (4), (3), (1), (1)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN650540
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human TMPRSS2 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human TMPRSS2 was used as an immunogen.
Alternative Name TMPRSS2
Background Transmembrane protease, serine 2 (TMPRSS2) is a type-II transmembrane serine protease. It encodes a type II trans-membrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. The biological function of TMPRSS2 is unknown, however, seine proteases are known to be involved in many physiological and pathological processes (1). TMPRSS2 is expressed highly in primary and metastatic prostate cancers. It is also regulated by androgens and is associated with tumor cell differentiation (1, 2), making it a potential target for cancer therapy and diagnosis. TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (3, 4).
Molecular Weight 54 kDA
Gene ID 5905
UniProt O15393
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:1000, WB: = 1:5000-10000
Comment

Background: Transmembrane protease, serine 2 (TMPRSS2) is a type-II transmembrane serine protease. It encodes a type II trans-membrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. The biological function of TMPRSS2 is unknown, however, seine proteases are known to be involved in many physiological and pathological processes (1). TMPRSS2 is expressed highly in primary and metastatic prostate cancers. It is also regulated by androgens and is associated with tumor cell differentiation (1, 2), making it a potential target for cancer therapy and diagnosis. TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (3, 4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TMPRSS2 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Korelitz, Sommers: "Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes." in: The American journal of gastroenterology, Vol. 64, Issue 5, pp. 365-70, 1976 (PubMed).

Hermans, van Marion, van Dekken et al.: "TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer." in: Cancer research, Vol. 66, Issue 22, pp. 10658-63, 2006 (PubMed).

Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).

Lucas, True, Hawley et al.: "The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma." in: The Journal of pathology, Vol. 215, Issue 2, pp. 118-25, 2008 (PubMed).

FitzGerald, Agalliu, Johnson et al.: "Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer." in: BMC cancer, Vol. 8, pp. 230, 2008 (PubMed).

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