|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Transmembrane Protease, serine 2 (TMPRSS2) antibody
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||A synthetic peptide corresponding to residues in human TMPRSS2 was used as an immunogen.|
|Characteristics||Rabbit Monoclonal Antibody|
|Specificity||A synthetic peptide corresponding to residues in human TMPRSS2 was used as an immunogen.|
|Molecular Weight||54 kDA|
Background: Transmembrane protease, serine 2 (TMPRSS2) is a type-II transmembrane serine protease. It encodes a type II trans-membrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. The biological function of TMPRSS2 is unknown, however, seine proteases are known to be involved in many physiological and pathological processes (1). TMPRSS2 is expressed highly in primary and metastatic prostate cancers. It is also regulated by androgens and is associated with tumor cell differentiation (1, 2), making it a potential target for cancer therapy and diagnosis. TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (3, 4).
|Application Notes||The suggested dilution is: WB: ~~ 1:5000~10000 IP: ~~ 1:50 ICC: ~~ 1:250~1000 IHC: ~~ 1:1000|
|Buffer||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||TMPRSS2 Antibody can be stored at -20°C for up to 12 months from time of receipt.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Korelitz, Sommers: "Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes." in: The American journal of gastroenterology, Vol. 64, Issue 5, pp. 365-70, 1976 (PubMed).
Hermans, van Marion, van Dekken et al.: "TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer." in: Cancer research, Vol. 66, Issue 22, pp. 10658-63, 2006 (PubMed).
Pruitt, Tatusova, Maglott: "NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins." in: Nucleic acids research, Vol. 35, Issue Database issue, pp. D61-5, 2007 (PubMed).
Lucas, True, Hawley et al.: "The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma." in: The Journal of pathology, Vol. 215, Issue 2, pp. 118-25, 2008 (PubMed).
FitzGerald, Agalliu, Johnson et al.: "Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer." in: BMC cancer, Vol. 8, pp. 230, 2008 (PubMed).
|Hosts||Rabbit (28), Goat (4)|
|Reactivities||Human (28), Cow (Bovine) (18), Mouse (Murine) (18), Pig (Porcine) (18), Rat (Rattus) (18), Sheep (Ovine) (18)|
|Applications||Immunofluorescence (IF) (15), Flow Cytometry (FACS) (14), ELISA (12), Western Blotting (WB) (12), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Dot Blot (DB) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Biotin (2), FITC (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||Isoform 2 (3), Internal Region (2), N-Term (2), Center (1)|