Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) antibody

Details for Product No. ABIN650544
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Antigen
Synonyms tnfaip3, MGC82339, TNFAIP3, A20, OTUD7C, TNFA1P2, Tnfip3
Reactivity
Human
(51), (33), (33), (12), (12), (12)
Host
Rabbit
(41), (7), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(39), (21), (20), (11), (10), (4), (1), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN650544
450.00 $
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Immunogen A synthetic peptide corresponding to residues in human TNFAIP3 was used as an immunogen.
Specificity A synthetic peptide corresponding to residues in human TNFAIP3 was used as an immunogen.
Alternative Name TNFAIP3
Background Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) is a de-ubiquitinating enzyme that contains an N-terminal catalytic domain belonging to the ovarian-tumour superfamily of cysteine proteases (1). TNFAIP3 suppresses apoptosis. It is expressed in various cell types in response to a variety of stimuli that activate the transcription factor NF-kB, including Il-1, CD40 ligand, and PMA (3). TNFAIP3 has been strongly suggested as a key protein involved in tamoxifen resistance, and thus represents both a new breast cancer marker and a promising target for developing new strategies to prevent the emergence of acquired mechanisms of drug resistance in breast cancer (2).
Synonyms: Putative DNA-binding protein A20, Zinc finger protein A20
Molecular Weight 80 kDA
Gene ID 7128
UniProt P21580
Research Area Apoptosis/Necrosis, Cell Signaling, Protein Modifications, Cell Structure, Signaling
Application Notes IHC: = 1:50-100, WB: = 1:1000-10000
Comment

Background: Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) is a de-ubiquitinating enzyme that contains an N-terminal catalytic domain belonging to the ovarian-tumour superfamily of cysteine proteases (1). TNFAIP3 suppresses apoptosis. It is expressed in various cell types in response to a variety of stimuli that activate the transcription factor NF-kB, including Il-1, CD40 ligand, and PMA (3). TNFAIP3 has been strongly suggested as a key protein involved in tamoxifen resistance, and thus represents both a new breast cancer marker and a promising target for developing new strategies to prevent the emergence of acquired mechanisms of drug resistance in breast cancer (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TNFAIP3 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Evans, Ovaa, Hamon et al.: "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 727-34, 2004 (PubMed).

Daniel, Arvelo, Patel et al.: "A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation." in: Blood, Vol. 104, Issue 8, pp. 2376-84, 2004 (PubMed).

Vendrell, Ghayad, Ben-Larbi et al.: "A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells." in: Oncogene, Vol. 26, Issue 32, pp. 4656-67, 2007 (PubMed).

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