Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (Extracellular) antibody

Details for Product No. ABIN650545
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Antigen
Epitope
Extracellular
(34), (28), (15), (14), (13), (13), (12), (12), (11), (7), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(282), (146), (74), (39), (28), (28), (25), (14), (9), (6), (6), (5), (5), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(245), (79), (22), (19), (14), (4), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(33), (32), (28), (13), (9), (9), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(242), (133), (130), (91), (89), (48), (38), (35), (33), (23), (17), (14), (12), (10), (10), (9), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
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Immunogen A synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen.
Specificity A synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen.
Alternative Name TNFR1 (TNFRSF1A Antibody Abstract)
Background Tumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-α,), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-α, has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- α, or homotrimeric lymphotoxin-α,, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2).
Synonyms: TNFRSF1A, TNFAR, TNFR1, Tumor necrosis factor-binding protein 1, p60,p55
Molecular Weight 55 kDA
Gene ID 7132
UniProt P19438
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways NF-kappaB Signaling
Application Notes The suggested dilution is: WB: = 1:500
Comment

Background: Tumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-α,), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-α, has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- α, or homotrimeric lymphotoxin-α,, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment TNFR1 Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Brenner, OHara, Angel et al.: "Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha." in: Nature, Vol. 337, Issue 6208, pp. 661-3, 1989 (PubMed).

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Catalog No. ABIN650545
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