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Vitamin D-Binding Protein (GC) antibody

Details for Product No. ABIN650599
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Antigen
Synonyms zgc:110389, zgc:92753, GC, DABP, Gc, DBP, DBP02, VDB, Vdbp, DBP/GC, GRD3, VDBG, VDBP, VTDB, 17-beta-HSD, 17[b]-HSD, 4, MFE-2, MFP2, MPF-2, Mfp-2, perMFE-2
Reactivity
Human
(85), (27), (26), (17), (12), (6), (1)
Host
Rabbit
(59), (22), (13), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(61), (54), (21), (12), (11), (10), (10), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
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Catalog No. ABIN650599
450.00 $
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Immunogen A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.
Specificity A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.
Alternative Name Vitamin D-binding protein
Background Vitamin-D binding protein (VDBP, DBP, Gc) is a multifunctional plasma protein that has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. It is a member of a multigene family including alpha-fetoprotein and albumin. It is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells. VDBP has a triple domain modular structure with extensive disulfide bonding that is characteristic of this protein family. VDBP receptors are constitutively expressed by malignant B-cells and in a transitory form by normal B-lymphocytes undergoing mitogen-induced activation (1-4).
Synonyms: GC, Vitamin D-binding protein, Group-specific component,Gc-globulin
Molecular Weight 52 kDA
Gene ID 2638
UniProt P02774
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes IHC: = 1:100-250, WB: = 1:1000-5000
Comment

Background: Vitamin-D binding protein (VDBP, DBP, Gc) is a multifunctional plasma protein that has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. It is a member of a multigene family including alpha-fetoprotein and albumin. It is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells. VDBP has a triple domain modular structure with extensive disulfide bonding that is characteristic of this protein family. VDBP receptors are constitutively expressed by malignant B-cells and in a transitory form by normal B-lymphocytes undergoing mitogen-induced activation (1-4).

Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Vitamin D-binding protein Antibody can be stored at -20°C for up to 12 months from time of receipt.
Expiry Date 12 months
Background publications Cooke, David: "Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family." in: The Journal of clinical investigation, Vol. 76, Issue 6, pp. 2420-4, 1986 (PubMed).

Validation Images
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