Vitamin D-Binding Protein (GC) antibody

Antigen: Vitamin D-Binding Protein (GC)

Synonyms: DBP, VDBG, VDBP, DBP/GC, zgc:110389, GC, MGC127742, Gc

Clonality: Monoclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Certificates: ISO 9001:2008

Catalog no.: ABIN650599

Additional Information

Alternative name: Vitamin D-binding protein

Gene ID: 2638

UniProt: P02774

Immunogen: A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.

Description: Other names: GC, Vitamin D-binding protein, Group-specific component,Gc-globulin

Characteristics: Rabbit Monoclonal Antibody

Specificity: A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.

Molecular Weight: 52 kDA

Comments:

Background: Vitamin-D binding protein (VDBP, DBP, Gc) is a multifunctional plasma protein that has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. It is a member of a multigene family including alpha-fetoprotein and albumin. It is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells. VDBP has a triple domain modular structure with extensive disulfide bonding that is characteristic of this protein family. VDBP receptors are constitutively expressed by malignant B-cells and in a transitory form by normal B-lymphocytes undergoing mitogen-induced activation (1-4).

Application Details

Application Notes: The suggested dilution is: WB: ~~ 1:1000~5000 IP: ~~ 1:10 FC: ~~ 1:50 ICC: ~~ 1:100~250 IHC: ~~ 1:100~250

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage: Vitamin D-binding protein Antibody can be stored at -20°C for up to 12 months from time of receipt.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Cooke, David: "Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family." in: The Journal of clinical investigation, Vol. 76, Issue 6, pp. 2420-4, 1986 (PubMed).