|+1 404 474 4654|
|+1 888 205 9894 (TF)|
SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (N-Term,Met1) antibody
|Synonyms||HSMT3, SMT3B, SMT3H2, MGC117191, zgc:92241, SUMO2|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human SUMO2/3.|
|Description||Other names: Small ubiquitin-related modifier 2, SUMO-2, Ubiquitin-like protein SMT3B, SMT3 homolog 2, Sentrin 2, HSMT3, SUMO-3, SMT3B, SMT3H2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human SUMO2/3.|
|Molecular Weight||10871 DA|
Background: SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
|Application Notes||Suggested Dilution: ELISA~~1:1,000 Western blotting~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Apoptosis/Necrosis, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Mannen, Tseng, Cho et al.: "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene." in: Biochemical and biophysical research communications, Vol. 222, Issue 1, pp. 178-80, 1996 (PubMed).
Lapenta, Chiurazzi, van der Spek et al.: "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family." in: Genomics, Vol. 40, Issue 2, pp. 362-6, 1997 (PubMed).
Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).
|Hosts||Rabbit (9), Mouse (2)|
|Reactivities||Human (12), Mouse (Murine) (3), Rat (Rattus) (3)|
|Applications||ELISA (11), Western Blotting (WB) (11), Immunohistochemistry (IHC) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (2)|
|Epitopes||C-Term (2), AA 1-93 (1), C-Term,Glu69 (1), Center (1), Cleaved-Gly93 (1), N-Term (1)|