Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) antibody

Details for Product No. ABIN650630
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Antigen
Reactivity
Human
(53), (15), (15)
Host
Rabbit
(45), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(53), (42), (24), (11), (7), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN650630
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Immunogen This SPRED1 antibody is generated from rabbits immunized with human SPRED1 recombinant protein.
Clone RB23008
Isotype Ig
Specificity This SPRED1 antibody is generated from rabbits immunized with human SPRED1 recombinant protein.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SPRED1
Background SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Synonyms: Sprouty-related, EVH1 domain-containing protein 1, Spred-1, SPRED1,
Molecular Weight 50477 Da
Gene ID 161742
UniProt Q7Z699
Research Area Stem Cells, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) antibody Western blot analysis of SPRED1 Antibody (ABIN650630) in Jurkat cell line lysates (35 µg/lane). SPRED1 (arrow) was detected using the purified polyclonal antibody.
anti-Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) antibody (2) SPRED1 Antibody (ABIN650630) flow cytometry analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Yoshida, Hisamoto, Akiba et al.: "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors." in: Oncogene, Vol. 25, Issue 45, pp. 6056-66, 2006 (PubMed).

Brems, Chmara, Sahbatou et al.: "Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype." in: Nature genetics, Vol. 39, Issue 9, pp. 1120-6, 2007 (PubMed).

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