Defective in Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) (DSCC1) (C-Term), (AA 311-339) antibody

Details for Product No. ABIN650755
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Antigen
Epitope
C-Term, AA 311-339
(7), (6), (3), (1), (1)
Reactivity
Human
(25), (11), (11), (11), (11)
Host
Rabbit
(24), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(16), (9), (9), (4), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN650755
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Immunogen This DCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-339 AA from the C-terminal region of human DCC1.
Clone RB27627
Isotype Ig
Specificity This DCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the C-terminal region of human DCC1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DCC1
Background CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176], Bermudez et al., 2003 [PubMed 12930902]).
Synonyms: Sister chromatid cohesion protein DCC1,DSCC1,DCC1
Molecular Weight 44825 DA
Gene ID 79075
NCBI Accession NP_076999
UniProt Q9BVC3
Research Area Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Defective in Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) (DSCC1) (C-Term), (AA 311-339) antibody DCC1 Antibody (C-term) (ABIN650755) western blot analysis in CEM cell line lysates (35 µg/lane).This demonstrates the DCC1 antibody detected the DCC1 protein (arrow).
Background publications Merkle, Karnitz, Henry-Sánchez et al.: "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30051-6, 2003 (PubMed).

Terret, Sherwood, Rahman et al.: "Cohesin acetylation speeds the replication fork." in: Nature, Vol. 462, Issue 7270, pp. 231-4, 2009 (PubMed).

Murakami, Takano, Takeo et al.: "Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34608-15, 2010 (PubMed).

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