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Defective in Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) (DSCC1) (AA 311-339), (C-Term) antibody

Details for Product No. ABIN650755, Supplier: Log in to see
Antigen
  • 2010006I05Rik
  • 2600005O03Rik
  • DCC1
  • Dcc1
  • RGD1561749
  • zgc:103507
Epitope
AA 311-339, C-Term
15
13
4
2
1
1
1
Reactivity
Human
59
13
13
Host
Rabbit
37
22
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
47
36
11
6
3
3
2
Supplier
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Immunogen This DCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-339 AA from the C-terminal region of human DCC1.
Clone RB27627
Isotype Ig
Specificity This DCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-347 amino acids from the C-terminal region of human DCC1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DCC1 (DSCC1 Antibody Abstract)
Background CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176], Bermudez et al., 2003 [PubMed 12930902]).
Synonyms: Sister chromatid cohesion protein DCC1,DSCC1,DCC1
Molecular Weight 44825 DA
Gene ID 79075
NCBI Accession NP_076999
UniProt Q9BVC3
Research Area Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Defective in Sister Chromatid Cohesion 1 Homolog (S. Cerevisiae) (DSCC1) (AA 311-339), (C-Term) antibody (ABIN650755) DCC1 Antibody (C-term) (ABIN650755) western blot analysis in CEM cell line lysates (3...
Background publications Murakami, Takano, Takeo, Taniguchi, Ogawa, Ohashi, Tsurimoto et al.: "Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, ..." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34608-15, 2010 (PubMed).

Terret, Sherwood, Rahman, Qin, Jallepalli: "Cohesin acetylation speeds the replication fork." in: Nature, Vol. 462, Issue 7270, pp. 231-4, 2009 (PubMed).

Merkle, Karnitz, Henry-Sánchez, Chen: "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30051-6, 2003 (PubMed).