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ABL2 (AA 417-446), (Arg432) antibody

Details for Product No. ABIN650789, Supplier: Log in to see
Antigen
  • AA536808
  • ABLL
  • Abll
  • ARG
  • Arg
Epitope
AA 417-446, Arg432
20
18
15
11
7
7
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
124
33
20
Host
Rabbit
84
40
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
6
6
6
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
104
82
27
24
12
11
11
5
5
2
1
1
1
Supplier
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Immunogen This ABL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 417-446 AA from human ABL2.
Clone RB7532
Isotype Ig
Specificity This ABL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ABL2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.
Synonyms: Tyrosine-protein kinase ABL2, Abelson murine leukemia viral oncogene homolog 2, Tyrosine kinase ARG, ABL2, ABLL, ARG,
Molecular Weight 128343 DA
Gene ID 27
UniProt P42684
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.43 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ABL2 (AA 417-446), (Arg432) antibody (ABIN650789) ABL2 non P-specific Pab (ABIN650789) western blot analysis in Y79 cell line lysates (...
Background publications Cao, Leng, Liu, Yi, Li, Kufe: "Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases." in: Biochemistry, Vol. 42, Issue 35, pp. 10348-53, 2003 (PubMed).

Cao, Leng, Kufe: "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 29667-75, 2003 (PubMed).

Kruh, Perego, Miki, Aaronson: "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 15, pp. 5802-6, 1990 (PubMed).

Kruh, King, Kraus, Popescu, Amsbaugh, McBride, Aaronson: "A novel human gene closely related to the abl proto-oncogene." in: Science (New York, N.Y.), Vol. 234, Issue 4783, pp. 1545-8, 1987 (PubMed).